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SAGE KE Highlights From Science's Table of Contents

[2006] [2005] [2004] [2003] [2002] [2001]

30 June 2006

I Come Not to Bury SAGE KE But to Appraise It E. Strauss.
One of the site's creators tells a personal story of its rise and demise.
[Abstract] [Full Text]

Death-Bed Prophecy M. Leslie.
On the eve of its termination, SAGE KE takes a look at the future of research on aging.
[Abstract] [Full Text]

Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for Treatment B. A. Tate and P. M. Mathews.
Alzheimer's disease-associated endosomal abnormalities might provide a route for drug-based interventions.
[Abstract] [Full Text]

Dementia with Cerebrovascular Disease C. B. Wright, J. P. G. Vonsattel, K. Bell, L. S. Honig.
A case study.
[Abstract] [Full Text]

WRN's Tenth Anniversary F. M. Hisama, V. A. Bohr, J. Oshima.
What have we learned about RecQ helicase function in a segmental progeroid syndrome and normal aging?
[Abstract] [Full Text]

The Unusual Genetics of Human Longevity G. De Benedictis and C. Franceschi.
Centenarians provide a unique opportunity for understanding "longevity genes."
[Abstract] [Full Text]

Aging On the Job J. Levine, J. Heet, B. Burlingame.
As the population ages, will the workforce decline along with it?
[Abstract] [Full Text]

The Role of Mitochondria in Conserved Mechanisms of Aging C. Scheckhuber and H. D. Osiewacz.
Report from the second "MiMage" symposium describes research on a variety of systems.
[Abstract] [Full Text]

Developing a Research Agenda in Biogerontology: Physiological Systems J. L. Carrington and F. L. Bellino.
Research supported by the National Institute on Aging aims to understand the biology of aging tissues.
[Abstract] [Full Text]

From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life? S. Studenski, M. C. Carlson, H. Fillit, W. T. Greenough, A. Kramer, G. W. Rebok.
Conference looks at the role of exercise for promoting mental health and delaying dementia.
[Abstract] [Full Text]

A Work in Progress: The Metabolic Syndrome J. A. Luchsinger.
Should we diagnose and treat the metabolic syndrome?
[Abstract] [Full Text]

Classic Paper: Mutation Selection and the Natural History of Cancer J. Cairns.
[Abstract] [PDF]

23 June 2006

Experimental Rodent Strains
Check out the biological characteristics of inbred and hybrid strains used to study aging.
[Strains]

Classic Papers
View historical (pre-1990) articles on aging-related topics.
[Classic Papers]

16 June 2006

Aging at the Interface of Stem Cell Renewal, Apoptosis, Senescence, and Cancer A. Nebel, E. Schaffitzel, M. Hertweck.
Scientists apply systems biology approaches to the field of aging-related research.
[Abstract] [Full Text]

Classic Paper: Pleiotropy, Natural Selection, and the Evolution of Senescence G. C. Williams.
The author discusses his theory of senescence.
[Abstract] [PDF]

9 June 2006

The Age of Cancer M. Leslie.
Cancer cells quiet gene behind premature aging disorder.
[Abstract] [Full Text]

Genetically Altered Mice: Werner Mice
Several strains designed to model a premature aging syndrome are described.
[Database]

2 June 2006

Pushing the Envelope M. Leslie.
Research blossoms on rare genetic disorders that might be linked to aging.
[Abstract] [Full Text]

Classic Paper: The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging L. E. Orgel.
The author discusses the "error catastrophe" hypothesis.
[Abstract] [PDF]

26 May 2006

Stem Cell Aging and Cancer J. Fuller.
Do stem cells age? Cancer studies may bring us closer to an answer.
[Abstract] [Full Text]

The Age of Skin Cancers A. Desai, R. Krathen, I. Orengo, E. E. Medrano.
Why are older men at greater risk for melanoma than older women?
[Abstract] [Full Text]

Shortcut to Death M. Leslie.
Stubby protein spurs cancer cells to eat themselves.
[Abstract] [Full Text]

19 May 2006

Toward a Better Understanding of Klotho Y. Nabeshima.
Analysis suggests a link between premature aging and calcium homeostasis.
[Abstract] [Full Text]

What Good Is Growing Old? M. Leslie.
Renegade researchers argue that aging is adaptive for the community.
[Abstract] [Full Text]

12 May 2006

Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream A. Nunomura, R. J. Castellani, H. Lee, P. I. Moreira, X. Zhu, G. Perry, M. A. Smith.
Are senile plaques and neurofibrillary tangles protective rather than pathogenic?
[Abstract] [Full Text]

Meetings and Events
The 10th International Conference on Alzheimer's Disease and Related Disorders will be held in Madrid in July.
[Calendar]

5 May 2006

A Shared Splice Site? M. Leslie.
Defect behind "premature aging" disorder might foster normal aging.
[Abstract] [Full Text]

Genes/Interventions Database: LMNA
Mutations that affect lamin A, a component of the nuclear lamina, cause Hutchinson-Gilford progeria syndrome.
[Database Entry]

28 April 2006

In Praise of Insulin Resistance M. Leslie.
Immune-cell metabolic defect might hinder atherosclerosis.
[Abstract] [Full Text]

Classic Paper: Effects of Food Restriction on Aging--Separation of Food Intake and Adiposity D. E. Harrison, J. Archer, C. M. Astle.
Genetically obese mice display extended longevity on a food-restricted diet.
[Abstract] [PDF]

21 April 2006

Aging in Check W. Dai and X. Wang.
Defects in two spindle checkpoint proteins lead to premature cell senescence and accelerated aging.
[Abstract] [Full Text]

Published Comments: Making Sense of SENS A. de Grey.
The author responds to criticisms in last week's Perspective on strategies for engineered negligible senescence.
[Comment]

14 April 2006

Environmental Movement M. Leslie.
Researchers are discovering how the molecules in cells' surroundings contribute to aging--and how tweaking them might rejuvenate tissues.
[Abstract] [Full Text]

Genes/Interventions Database: Plau
Overproduction of an extracellular protease in the brain is associated with life-span extension in mice.
[Database Entry]

7 April 2006

SENS and the Polarization of Aging-Related Research D. A. Gray and A. B�rkle.
Controversy surrounds the "strategies for engineered negligible senescence" concept and conference.
[Abstract] [Full Text]

Tag-Team Recycling M. Leslie.
Mechanisms for protein disposal interact.
[Abstract] [Full Text]

31 March 2006

Small-Fiber Neuropathy: Answering the Burning Questions E. Fink and A. L. Oaklander.
New techniques offer promise for diagnosing peripheral nerve disease.
[Abstract] [Full Text]

Teaching Resources Check out the figures, outlines, and other teaching materials suitable for courses on the science of aging.
[Resources]

24 March 2006

The Development of Amyloid β Protein Deposits in the Aged Brain D. R. Thal, E. Capetillo-Zarate, K. Del Tredici, H. Braak.
Different types of amyloid β protein deposits offer clues into the development of neurodegeneration.
[Abstract] [Full Text]

Aging in the Arts View a painting of moon goddess Chang E, who purportedly stole the elixir of immortality from her husband.
[Painting]

17 March 2006

Buffing Up the Family Jewels M. Beckman.
Obliterating a protein that fosters testosterone production keeps testicles young.
[Abstract] [Full Text]

Classic Paper: The Neuroendocrinology of Stress and Aging--The Glucocorticoid Cascade Hypothesis R. M. Sapolsky, L. C. Krey, B. S. McEwen.
Termination of adrenocortical stress hormone secretion is impaired in aged male rats.
[Abstract] [PDF]

10 March 2006

Craving an Answer M. Leslie.
After 70 years, researchers might be closing in on how calorie restriction extends life.
[Abstract] [Full Text]

Classic Paper: Action of Food Restriction in Delaying the Aging Process E. J. Masoro, B. P. Yu, H. A. Bertrand.
Decreased metabolic rate might not explain why food restriction slows aging.
[Abstract] [PDF]

3 March 2006

Genes/Interventions Database
Heat shock extends life span of yeast, worms, and flies.
[Database]

Meetings and Events
American Aging Association meeting in June will focus on interventions in aging and age-related diseases.
[Calendar]

24 February 2006

The Sour Side of Sweet M. Leslie.
Sugar derivatives take a toll on cells.
[Abstract] [Full Text]

Classic Paper: Detection of Inactive Enzyme Molecules in Ageing Organisms H. Gershon and D. Gershon.
Accumulation of nonfunctional proteins may play a key role in senescence.
[Abstract] [PDF]

17 February 2006

When Good Cdk5 Turns Bad Q. Guo.
Prolonged activation of the cyclin-dependent kinase-5 leads to neurodegeneration.
[Abstract] [Full Text]

Mucking With Metabolism M. Beckman.
Inability to repair DNA damage in mitochondria could foster metabolic syndrome.
[Abstract] [Full Text]

10 February 2006

Olfactory Loss in Aging N. E. Rawson.
Why does perception of volatile stimuli decline with age?
[Abstract] [Full Text]

3 February 2006

Meetings and Events
Learn about free radicals, innate immunity, cardiac regeneration, and more at this month's aging-related meetings.
[Calendar]

Web Links
Find links to databases, funding agencies, and labs conducting aging-related research.
[Web Links]

27 January 2006

Prion 2005--Between Fundamentals and Society's Needs C. Treiber.
Conference goes a step further in coordinating and reinforcing international research activities.
[Abstract] [Full Text]

The Way of the Honeybee M. Leslie.
Bees turn reproductive protein into antioxidant.
[Abstract] [Full Text]

20 January 2006

Dividing to Keep Muscle Together--The Role of Satellite Cells in Aging Skeletal Muscle R. T. Hepple.
Impaired satellite cell function might contribute to aging muscle atrophy.
[Abstract] [Full Text]

Double Duty M. Leslie.
Cholesterol-reducing receptor also curbs blood glucose.
[Abstract] [Full Text]

13 January 2006

Lessons from Drosophila Models of DJ-1 Deficiency D. J. Moore, V. L. Dawson, T. M. Dawson.
Fly models generally fail to exhibit key features of Parkinson's disease.
[Abstract] [Full Text]

Chain of Command M. Leslie.
Study fingers abettors of life-streching protein.
[Abstract] [Full Text]

6 January 2006

Biomarkers of Aging�Combinatorial or Systems Model? A. Kriete.
New bioinformatics search strategies might snare elusive biomarkers.
[Abstract] [Full Text]

Uncoupling Insulin M. Leslie.
SIRT1 boosts insulin release by blocking mitochondrial protein.
[Abstract] [Full Text]

23 December 2005

Harnessing Hormonal Signaling for Cardioprotection V. L. Ballard and J. M. Edelberg.
The jury is still out when it comes to a beneficial role for estrogen on the heart.
[Abstract] [Full Text]

Loose Chromosomes Sink Cells M. Leslie.
Gene-silencing mechanism falters in patients with premature aging disorder.
[Abstract] [Full Text]

16 December 2005

When T Cells Get Old G. Pawelec.
Is remediation possible for immunosenscence?
[Abstract] [Full Text]

Oxidants off the Hook? M. Leslie.
Fast-aging mice don't suffer oxidative overload.
[Abstract] [Full Text]

9 December 2005

Living Longer and Paying the Price? J. Q. Trojanowski, M. K. Jedrziewski, D. A. Asch.
Conference featured discussion of health care costs and longevity in America.
[Abstract] [Full Text]

Tapping Into Renewal M. Leslie.
Compound that boosts cell division slows Huntington's disease in mice.
[Abstract] [Full Text]

2 December 2005

T Cell Immunity and Aging S. D. Koch, J. Kempf, G. Pawelec.
Consortium reviews progress in understanding immunosenescence.
[Abstract] [Full Text]

Down with p53! M. Leslie.
Curtailing cancer-fighting protein's activity lengthens fly life.
[Abstract] [Full Text]

25 November 2005

Mitochondrial Dynamics in Cell Life and Death C. Scheckhuber.
Results discussed at a workshop on mitochondrial fusion and fission have relevance to apoptosis and aging.
[Abstract] [Full Text]

Shortchanged by Sir2 M. Leslie.
Longevity protein cuts off yeast survival.
[Abstract] [Full Text]

18 November 2005

Bionic Grandma R. J. Davenport.
Engineered tissues might someday rejuvenate the elderly.
[Abstract] [Full Text]

Immune Shaping and the Development of Alzheimer's Disease Vaccines H. J. Federoff and W. J. Bowers.
The search is on for efficacious AD vaccines that do not promote dangerous brain inflammation.
[Abstract] [Full Text]

A Switch in Time Saves Mind M. Leslie.
Aging rats preserve their memory by adjusting their response to stimulation.
[Abstract] [Full Text]

11 November 2005

Mitochondrial Genetics of Aging--Intergenomic Conflict Resolution D. M. Rand.
Understanding biochemical and genetic conflicts between mitochondria and nucleus sheds light on aging.
[Abstract] [Full Text]

Cancer Connection M. Leslie.
Tumor-fighter throttles life-extending protein SIRT1.
[Abstract] [Full Text]

4 November 2005

Developing a Research Agenda in Biogerontology: Basic Mechanisms H. R. Warner.
The author describes how research initiatives have been developed at the National Institute on Aging over the past two decades.
[Abstract] [Full Text]

Drug Bust M. Leslie.
Prescribing growth hormone to fight aging is illegal.
[Abstract] [Full Text]

28 October 2005

Neurochemical Insights C. Treiber.
Scientists aggregate in Austria to discuss neurodegenerative disease and brain function.
[Abstract] [Full Text]

Trapped Inside M. Leslie.
Pumping-protein failure might spur Alzheimer's disease.
[Abstract] [Full Text]

Caught With Their Proboscises in the Sugar Water M. Leslie.
Flies on life-extending diet eat more than expected.
[Abstract] [Full Text]

21 October 2005

What's Bugging You? M. Leslie.
Bacteria and viruses that attack us in our youths might return to cause some of the scourges of old age.
[Abstract] [Full Text]

Gone to Flab M. Leslie.
Overactive lipid-generating enzyme might spur muscles to pack in fat.
[Abstract] [Full Text]

14 October 2005

C. elegans Gives the Dirt on Aging M. Hertweck.
Presentations at the 15th International C. elegans Meeting provide new insights on aging.
[Abstract] [Full Text]

Fatal Hunger M. Leslie
Aging eggs might starve to death.
[Abstract] [Full Text]

7 October 2005

Revising the Standard Wisdom of C. elegans Natural History: Ecology of Longevity E. P. Caswell-Chen, J. Chen, E. E. Lewis, G. W. Douhan, S. A. Nadler and J. R. Carey.
A symbiotic relationship between C. elegans and snails provides a new context for understanding the evolution of the worm and its life history traits.
[Abstract] [Full Text]

Turning Back the Clock R. J. Davenport.
Cancer drugs reverse nuclear defects of progeria.
[Abstract] [Full Text]

Cut the Fat M. Leslie.
Enzyme restores lipid-damaged DNA.
[Abstract] [Full Text]

30 September 2005

From Bedside to Bench: Research in Comorbidity and Aging G. D. Wieland.
Conference discusses the challenge of treating multiple overlapping health problems in the elderly.
[Abstract] [Full Text]

Appetite Suppressant M. Leslie.
Suicide-squelching molecule also slows cellular cannibalism.
[Abstract] [Full Text]

Battle of the Sexes R. J. Davenport.
Male bean weevils shape female aging.
[Abstract] [Full Text]

23 September 2005

Membrane Permeabilization: A Common Mechanism in Protein-Misfolding Diseases H. A. Lashuel.
If it looks like a pore and acts like a pore, is it a pathogenic pore?
[Abstract] [Full Text]

Plumbing Problem M. Leslie.
Lymph system malfunctions might promote obesity.
[Abstract] [Full Text]

Two Ways About It R. J. Davenport.
Phosphate-adding proteins send neurons down different roads to death after a stroke.
[Abstract] [Full Text]

16 September 2005

Good Timing R. J. Davenport.
Circadian clock teams with appetite-suppressing hormone to temper bone growth.
[Abstract] [Full Text]

Genes/Interventions Database
This database contains information about genes and interventions that have been studied with respect to their effects on life span or age-related neurological diseases.
[Database]

9 September 2005

Metals on the Brain C. Treiber.
Conference featured new results on metal-ion homeostasis and neurodegenerative disease.
[Abstract] [Full Text]

Get Out of the Way R. J. Davenport.
Parathyroid hormone builds more bone when a similar protein is absent.
[Abstract] [Full Text]

No Parkin Zone M. Leslie.
Researchers nab possible cell killer in Parkinson's disease.
[Abstract] [Full Text]

2 September 2005

Interfering with Longevity S. S. Lee.
RNA interference has transformed aging-related research in worms.
[Abstract] [Full Text]

Another Knock Against Cholesterol M. Leslie.
Artery clogger might promote Alzheimer's disease when damaged.
[Abstract] [Full Text]

Numb Together R. J. Davenport.
Protein relative of p53 has opposite influence on aging.
[Abstract] [Full Text]

26 August 2005

Brain Tumor-Associated Dementia J. McC. Noble, P. Canoll and L. S. Honig.
This study describes an unusual cause of cognitive decline.
[Abstract] [Full Text]

Tuning Up the Pancreas M. Leslie.
Mammalian version of yeast longevity protein boosts efficiency of insulin-making cells.
[Abstract] [Full Text]

Family Fued R. J. Davenport.
Protein relative of p53 has opposite influence on aging.
[Abstract] [Full Text]

19 August 2005

Making Young Tumors Old: A New Weapon Against Cancer? J. Sage.
Oncogene-induced senescence acts as a tumor suppressor mechanism.
[Abstract] [Full Text]

Beta Testing M. Leslie.
Lethargic pancreas gene might unleash diabetes.
[Abstract] [Full Text]

Hairy Breakup M. Beckman.
Alone, protein that replenishes chromosome ends finds capacity to fire up hair stem cells.
[Abstract] [Full Text]

12 August 2005

BRI-A{beta}42 Transgenic Mice Q. Guo.
Mice that produce human Aβ1-42 in the absence of human amyloid precursor protein production develop amyloid-related pathologies.
[Abstract] [Full Text]

BRI-A{beta}40 Transgenic Mice Q. Guo.
Mice that produce human Aβ1-40 in the absence of human amyloid precursor protein production do not develop amyloid-related pathologies.
[Abstract] [Full Text]

Partly Cloudy R. J. Davenport.
Mice with Alzheimer's disease-linked gene variants suffer deteriorating retinas.
[Abstract] [Full Text]

Up to Speed M. Leslie.
Amphetamines spare mice from Parkinson's disease-like symptoms.
[Abstract] [Full Text]

5 August 2005

From Bedside to Bench: Research Agenda for Frailty L. P. Fried, E. C. Hadley, J. D. Walston, A. Newman, J. M. Guralnik, S. Studenski, T. B. Harris, W. B. Ershler and L. Ferrucci.
Conference aims for a better understanding of the physiology and etiology of this condition.
[Abstract] [Full Text]

Not a Chip off the Old Block M. Leslie.
Study identifies unexpected function for mammalian version of yeast longevity protein.
[Abstract] [Full Text]

Detour to Death R. J. Davenport.
Protein kills cells by diverting electrons and crafting free radicals.
[Abstract] [Full Text]

29 July 2005

How Long Do I Have, Doc? M. Leslie.
Protein foretells life span of genetically identical nematodes.
[Abstract] [Full Text]

Fat-Free Longevity R. J. Davenport.
Mutation spurs fat accumulation and longevity through separate paths.
[Abstract] [Full Text]

22 July 2005

Allelic Variation and Human Longevity A. Nebel and S. Schreiber.
Careful study design is key to the search for genetic differences that impact longevity.
[Abstract] [Full Text]

Error Prone R. J. Davenport.
Mitochondrial mutations might speed aging through rampant cell suicide.
[Abstract] [Full Text]

Bombshell M. Leslie.
Radioactive dating reveals cellular ages.
[Abstract] [Full Text]

15 July 2005

Aging Down Under S. J. Olshansky.
New organization promotes aging-related research in Australia.
[Abstract] [Full Text]

Pathological Partnership M. Leslie.
Study fingers p53 as an accomplice in Huntington's disease.
[Abstract] [Full Text]

Not Like the Other R. J. Davenport.
Older identical twins acquire different chromosome marks.
[Abstract] [Full Text]

8 July 2005

T-CIA: Investigating T Cells in Aging S. Koch, J. Kempf, G. Pawelec.
European program aims to understand immune dysregulation in the elderly.
[Abstract] [Full Text]

Hair Trigger R. J. Davenport.
Molecule induces skin cells to construct hair follicles.
[Abstract] [Full Text]

Odd SOD M. Leslie.
Out-of-shape proteins speed death in neuron-destroying disease.
[Abstract] [Full Text]

1 July 2005

Reactive Oxygen Species and Aging: Evolving Questions L. L. Dugan and K. L. Quick.
How do ROS contribute to aging in higher organisms?
[Abstract] [Full Text]

Metabolomics: Opening Another Window into Aging B. S. Kristal and Y. I. Shurubor.
What can analysis of the metabolome tell us about aging?
[Abstract] [Full Text]

Will We Find Biomarkers of Aging? R. J. Davenport.
Science's 125th anniversary special issue.
[Abstract] [Full Text]

How Can We Use Moderate Stresses to Fortify Humans and Slow Aging? M. Leslie.
Science's 125th anniversary special issue.
[Abstract] [Full Text]

How Can We Craft a Better Theory to Explain the Evolution of Aging? M. Leslie.
Science's 125th anniversary special issue.
[Abstract] [Full Text]

24 June 2005

Endothelial Progenitor Cell Therapy for Atherosclerosis: The Philosopher's Stone for an Aging Population? J. Kravchenko, P. J. Goldschmidt-Clermont, T. Powell, E. Stallard, I. Akushevich, M. S. Cuffe, K. G. Manton.
Effect of therapy on human life span is predicted to be comparable to that caused by eliminating cancer.
[Abstract] [Full Text]

Sticking It to Parkinson's Disease M. Leslie.
Vaccination spares mice from brain damage.
[Abstract] [Full Text]

Releasing the Pressure R. J. Davenport.
Eliminating kidney protein in mice relieves swelling spurred by diabetes drugs.
[Abstract] [Full Text]

17 June 2005

CB1 Knockout Mice M. Russell.
Cannabinoid receptors are involved in the control of bone mass and osteoclast activity.
[Full Text]

Before Their Time R. J. Davenport.
Eggs falter prematurely in mice without signaling molecule.
[Abstract] [Full Text]

Premature Emission M. Leslie.
Early surge in fat-fighting hormone might trigger obesity later in life.
[Abstract] [Full Text]

10 June 2005

The Longevity Gender Gap: Are Telomeres the Explanation? A. Aviv, J. Shay, K. Christensen, W. Wright.
Somatic cell selection might promote longevity in women.
[Abstract] [Full Text]

Why Females Live Longer Than Males: Control of Longevity by Sex Hormones J. Vi�a, C. Borr�s, J. Gambini, J. Sastre, F. V. Pallard�.
Estrogens might prolong life by increasing expression of antioxidant enzymes.
[Abstract] [Full Text]

Mars and Venus R. J. Davenport.
Unearthing the reasons that age-related diseases afflict men and women differently might improve health care for both sexes.
[Abstract] [Full Text]

3 June 2005

Misdirection on the Road to Shangri-La S. J. Olshansky, B. A. Carnes, R. Hershow, D. Passaro, J. Layden, J. Brody, L. Hayflick, R. N. Butler, D. S. Ludwig.
The authors respond to a recent Perspective on a potential decrease in life expectancy.
[Abstract] [Full Text]

Ties That Bind the Brain R. J. Davenport.
Parkin and glutathione deficits slay dopamine-producing neurons in flies.
[Abstract] [Full Text]

New Trick for an Old Enzyme M. Leslie.
Famous as a chromosome capper, telomerase might also orchestrate general DNA repair.
[Abstract] [Full Text]

27 May 2005

Nitric Oxide and Oxidative Stress in Cardiovascular Aging S. V. Y. Raju, L. A. Barouch, J. M. Hare.
Researchers say NO thanks to oxidative stress.
[Abstract] [Full Text]

The Skeleton Goes to Pot R. J. Davenport.
Prodding marijuana receptors spurs bone loss.
[Abstract] [Full Text]

Hush, Little Gene M. Leslie.
Mystery molecule helps gene-quieting protein mothball DNA.
[Abstract] [Full Text]

20 May 2005

MiMage: A Pan-European Project on the Role of Mitochondria in Aging C. Scheckhuber and H. D. Osiewacz.
European researchers focus on mitochondria to pinpoint conserved mechanisms of aging.
[Abstract] [Full Text]

Spring Forward R. J. Davenport.
March babies hit menopause earliest.
[Abstract] [Full Text]

13 May 2005

Keep Time, Stay Healthy G. Block.
Is sleep-cycle disruption the reason altered circadian rhythm causes metabolic syndrome?
[Abstract] [Full Text]

Death in the Dirt M. Leslie.
Long-lived in the petri dish, mutant worms bite the dust in soil.
[Abstract] [Full Text]

Heart, Heal Thyself M. Leslie.
Researchers turn on possible heart-repair mechanism.
[Abstract] [Full Text]

6 May 2005

Carnosine: A Versatile Antioxidant and Antiglycating Agent V. P. Reddy, M. R. Garrett, G. Perry, M. A. Smith.
Will carnosine come of AGE as a therapeutic agent for diseases involving oxidative damage?
[Abstract] [Full Text]

Good as New M. Leslie.
Researchers uncover genetic instructions for remaking worm body.
[Abstract] [Full Text]

Oxygen Poisoning and X-irradiation: A Mechanism in Common R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, and W. O. Fenn
[Abstract] [Full Text]

29 April 2005

The Art and Science of Anti-Aging Therapies J. Q. Trojanowski, M. K. Jedrziewski, B. Johnson, L. A. Whitaker.
Scientists discuss the convergence of theory and practice at a recent meeting.
[Abstract] [Full Text]

Shields Down M. Leslie.
Alzheimer's protein kills by tampering with cell's antioxidant defenses.
[Abstract] [Full Text]

Optimistic for Longevity R. J. Davenport.
High spirits reduce numbers of disease-linked molecules.
[Abstract] [Full Text]

22 April 2005

DJ-1�/� Mice J. Fuller.
Mouse model of Parkinson's disease suggests that DJ-1 protects neurons from oxidative stress.
[Full Text]

Harden My Heart R. J. Davenport.
Gene spurs blood vessels to amass calcium deposits.
[Abstract] [Full Text]

Sins of Synuclein M. Leslie.
Chemical attachments turn Parkinson's protein into cell killer.
[Abstract] [Full Text]

Defining the Diet R. J. Davenport.
Single ingredient might hold key to calorie restriction's benefits.
[Abstract] [Full Text]

15 April 2005

Time and Aging--Mechanisms and Meanings E. Wollscheid-Lengeling.
Whether we're killing ourselves by becoming too fat is a hefty question.
[Abstract] [Full Text]

Inflaming Chronic Pain M. Leslie.
Immune cells might trigger mysterious untreatable pain.
[Abstract] [Full Text]

8 April 2005

Future Mortality: A Bumpy Road to Shangri-La? S. Tuljapurkar.
Whether we're killing ourselves by becoming too fat is a hefty question.
[Abstract] [Full Text]

Dementia of the Alzheimer's Type and Accelerated Aging in Down Syndrome D. A. Devenny, J. Wegiel, N. Schupf, E. Jenkins, W. Zigman, S. J. Krinsky-McHale, and W. P. Silverman.
A case study.
[Abstract] [Full Text]

Power Cut M. Leslie.
Older mitochondria lose their oomph.
[Abstract] [Full Text]

Giant Steps R. J. Davenport.
Under tension, massive muscle protein relays signal to nucleus.
[Abstract] [Full Text]

1 April 2005

Feeling Spunky With JNK R. J. Davenport.
Protein funnels stress signals into insulin pathway and extends life.
[Abstract] [Full Text]

Mopping Up Nuclear Waste M. Leslie.
Molecule helps dispose of damaged proteins in the cell's command center.
[Abstract] [Full Text]

25 March 2005

Age-Related Neurodegenerative Changes and How They Affect the Gut P. R. Wade and P. J. Hornby.
Although the gut "loses its mind" with age, it remains relatively functional.
[Abstract] [Full Text]

b Blocker R. J. Davenport.
Diabetes-linked mutations cripple gene-control protein in pancreas cells.
[Abstract] [Full Text]

Hormone Give-and-Take M. Leslie.
Paucity of growth hormone doesn't buy extra time for rats.
[Full Text]

18 March 2005

The Genetic Basis of Aging: An Evolutionary Biologist's Perspective David N. Reznick.
Analyses of aging in model organisms offer a limited view of how senescence occurs.
[Abstract] [Full Text]

How Low Can You Go? R. J. Davenport.
Molecule might improve statins' cholesterol-depleting power.
[Abstract] [Full Text]

Outrunning Alzheimer's Disease M. Leslie.
Exercise curbs b amyloid buildup in mice.
[Abstract] [Full Text]

11 March 2005

Park2tm1Rpa Mice J. Fuller.
Mice designed to model a heritable form of Parkinson's disease do not exhibit parkinsonism.
[Full Text]

Sugar Rush M. Leslie.
Potential life-extending enzyme cranks up glucose synthesis.
[Abstract] [Full Text]

Early Warning R. J. Davenport.
Memory fades when b amyloid accumulates inside neurons.
[Abstract] [Full Text]

4 March 2005

Oxidative Mutagenesis, Mismatch Repair, and Aging A. M. Skinner and M. S. Turker.
Does oxidative stress both cause DNA damage and compromise mismatch repair?
[Abstract] [Full Text]

Will Humans Join the Club? R. J. Davenport.
Changes in insulin-signaling genes might extend human longevity.
[Abstract] [Full Text]

25 February 2005

Meeting Report: 4th European Congress of Biogerontology D. A. Gray and A. B�rkle.
Experts provided new insights into the fundamental mechanisms of aging.
[Abstract] [Full Text]

A New Biogerontology Lab in Newcastle D. A. Gray.
The University of Newcastle recently celebrated the opening of the Henry Wellcome Laboratory for Biogerontology Research.
[Abstract] [Full Text]

Stiff Competition R. J. Davenport.
Protein keeps joints from seizing up.
[Abstract] [Full Text]

The Two Faces of Leptin M. Leslie.
Fat-fighting hormone can strengthen, as well as weaken, the skeleton.
[Abstract] [Full Text]

18 February 2005

More Is Less: Neurogenesis and Age-Related Cognitive Decline in Long-Evans Rats J. L. Bizon and M. Gallagher.
Does neurogenesis help or hinder brain function?
[Abstract] [Full Text]

Now Hear This M. Leslie.
Gene therapy alleviates deafness in rodents.
[Abstract] [Full Text]

Short Circuit, Long Life R. J. Davenport.
Sloppy wiring in mitochondria extends fly longevity.
[Abstract] [Full Text]

11 February 2005

Drug Discovery in Neurodegenerative Diseases H. Geerts, J. Q. Trojanowski, V. M.-Y. Lee.
New research is meeting the need for drugs to counter neurodegeneration.
[Abstract] [Full Text]

Dosed to Death R. J. Davenport.
Thyroid hormone treatments shorten mouse life span.
[Abstract] [Full Text]

The Better to See You With M. Leslie.
Older folks surpass youngsters in discerning one kind of motion.
[Abstract] [Full Text]

7 February 2005

Lipofuscin and Aging: A Matter of Toxic Waste D. A. Gray, J. Woulfe.
Accumulation of this pigment might cause catastrophic lysosomal and proteasomal inhibition.
[Abstract] [Full Text]

Ageless No More M. Leslie.
Once thought immortal, gut bacteria suffer aging's toll.
[Abstract] [Full Text]

Plugged Up R. J. Davenport.
Broken pump abets calcium overload after a stroke.
[Abstract] [Full Text]

28 January 2005

Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts M. E. Obrenovich, V. M. Monnier.
AGE-modified extracellular matrix protein promotes programmed cell death.
[Abstract] [Full Text]

Coming Back for Seconds R. J. Davenport.
Extra doses of lipin protein spur obesity.
[Abstract] [Full Text]

Led Astray M. Leslie.
Worn-out cells prod healthy ones toward cancer.
[Abstract] [Full Text]

21 January 2005

Diabetes and Stem Cell Researchers Turn to the Lowly Spleen S. Kodama, M. Davis, D. L. Faustman.
Splenic stem cells might offer hope for the treatment of aging-related disease.
[Abstract] [Full Text]

Pay at the Pump R. J. Davenport.
Scans of failing hearts in patients reveal an energy crisis.
[Abstract] [Full Text]

14 January 2005

Zmpste24-/- Mice J. Fuller.
Reducing prelamin A abundance abolishes progeria-like phenotypes.
[Full Text]

Counting Down to Arthritis M. Leslie.
Extra repeated amino acid in a joint protein might promote cartilage breakdown.
[Abstract] [Full Text]

Worth Its Salt R. J. Davenport.
Elusive enzyme generates hormone that lowers blood pressure.
[Abstract] [Full Text]

7 January 2005

Report on the 14th Annual Meeting of the German Society for Geriatric Research C. Scheckhuber.
An eclectic view of German research on aging.
[Abstract] [Full Text]

Mix and Mismatch M. Leslie.
Cancer-promoting protein introduces mistakes in DNA pairing.
[Abstract] [Full Text]

New Age R. J. Davenport.
Novel method clocks yeast longevity.
[Abstract] [Full Text]

24 December 2004

Telomeres and Human Aging: Facts and Fibs A. Aviv.
The jury is still out on whether telomere dynamics is a surrogate for or a key determinant of human aging.
[Abstract] [Full Text]

Once More, With Feeling R. J. Davenport.
Hobbling glycation-detecting protein restores feeling in diabetic mice.
[Abstract] [Full Text]

Trashing Vision M. Leslie.
Cell receptor helps prevent garbage pileups in the eye.
[Abstract] [Full Text]

Natural Foods R. J. Davenport.
Wild-like pattern of feast and famine extends Medfly life span.
[Abstract] [Full Text]

Telltale Text M. Leslie.
Novelist's final work reveals early signs of Alzheimer's disease.
[Abstract] [Full Text]

17 December 2004

Gdf5-Cre/BmpR1afloxP Mice J. Fuller.
This strain serves as a model of osteoarthritis.
[Full Text]

Switching on Longevity M. Leslie.
Energy-measuring molecule might stretch life span.
[Abstract] [Full Text]

Ignorance Is Bliss M. Beckman.
Treatment makes cells from people with premature aging disorder overlook genetic abnormality and behave normally.
[Abstract] [Full Text]

Buddy System M. Beckman.
Young blood helps old muscle heal.
[Abstract] [Full Text]

Toxic Spill M. Beckman.
Parkin protects dopamine cargo within neurons from leaking.
[Abstract] [Full Text]

10 December 2004

Poly(ADP-Ribosyl)ation, PARP, and Aging S. Beneke and A. B�rkle.
PARP enzymes serve to protect the genome.
[Abstract] [Full Text]

Young at Brain M. Leslie.
Long-lived mice pump out extra neurons.
[Abstract] [Full Text]

3 December 2004

Mitochondrial Injury: A Hot Spot for Parkinsonism and Parkinson's Disease? B. I. Giasson.
Mutations in distinct genes might lead to Parkinson's disease through a common mechanism.
[Abstract] [Full Text]

Paying the Price R. J. Davenport.
Long-lived worms can't compete.
[Abstract] [Full Text]

Partners in Death M. Leslie.
Alzheimer's protein rouses cell-suicide enzyme.
[Abstract] [Full Text]

26 November 2004

Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around K. Pardee, J. Reinking, and H. Krause.
Transcription factors link lipid metabolism and aging-related processes.
[Abstract] [Full Text]

Young at Heart R. J. Davenport.
Life-extending mutation preserves fly hearts.
[Abstract] [Full Text]

Pay by the Pound M. Leslie.
Added weight might take a toll on the brain.
[Abstract] [Full Text]

19 November 2004

F344BNF1 and BNF344F1 Hybrid Rats D. J. Holmes.
Hybrid strains are longer-lived and healthier than the parental strains.
[Abstract] [Full Text]

Culture Clash R. J. Davenport.
Yeast cells might sign suicide pact, but the idea remains controversial.
[Abstract] [Full Text]

Ironing Out Cell Death M. Leslie.
Metal-grabbing enzyme saves suicidal cells.
[Abstract] [Full Text]

Solving the Energy Crisis R. J. Davenport.
Signaling molecule spurs cells to generate mitochondria.
[Abstract] [Full Text]

12 November 2004

Proteomics in Aging-Related Research A. Gafni.
How many proteins does it take to age a cell?
[Abstract] [Full Text]

Out of Whack, Out of Mind M. Leslie.
Misaligned brain cells might sap memory as we age.
[Abstract] [Full Text]

5 November 2004

The Search for Biomarkers of Aging: Next Stop INK4a/ARF Locus G. P. Dimri.
Expression of two tumor suppressors increases markedly with age.
[Abstract] [Full Text]

Gut Instinct M. Leslie.
Intestinal microbes promote fat buildup in mice.
[Abstract] [Full Text]

Relay Man R. J. Davenport.
Molecule transmits estrogen's bone-saving signal through T cells.
[Abstract] [Full Text]

29 October 2004

Prey for Long Life R. J. Davenport.
The hunted don't necessarily age quickly.
[Abstract] [Full Text]

Stuck in the Skin M. Leslie.
Blood fats waylay immune cells.
[Abstract] [Full Text]

Amyloid Precursor Protein (APP) E693Q Transgenic Mice (APPDutch Mice) G. Zitnik.
This strain is a model for hereditary cerebral hemorrhage with amyloidosis.
[Full Text]

The Goldilocks Genes M. Leslie.
Having too many or too few copies of a gene might incite disease or accelerate aging.
[Abstract] [Full Text]

22 October 2004

Aging-Related Research in the "-omics" Age M. Kaeberlein.
Genome-wide analyses should provide insight into aging and longevity.
[Abstract] [Full Text]

Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future S. Melov and A. Hubbard.
Microarray-based experiments present special problems and require careful design.
[Abstract] [Full Text]

Gone to Waste M. Leslie.
Inflammation-producing compound spurs muscle deterioration.
[Abstract] [Full Text]

Sticky Situation M. Beckman.
DNA landing sites for worm hibernation protein might flag aging-associated genes.
[Abstract] [Full Text]

Wilting Weed? R. J. Davenport.
Arabidopsis might provide new insights into the workings of protein linked to a premature aging disease.
[Abstract] [Full Text]

15 October 2004

Nuns and Monkeys: Investigating the Behavior of our Oldest Old J. A. Corr.
Studies of elderly people and nonhuman primates enhance each other.
[Abstract] [Full Text]

Homing In on a Hormone R. J. Davenport.
Telomerase aggravates oxidative damage in mitochondria.
[Abstract] [Full Text]

Wayward Sisters M. Beckman.
Progestin siblings exert opposite effects on monkey hearts.
[Abstract] [Full Text]

8 October 2004

Genes, Longevity and Technology: Meeting Report from the 2nd Conference on Functional Genomics of Aging in Crete R. Baumeister and M. Hertweck.
Scientists discuss aging from a systems viewpoint.
[Abstract] [Full Text]

Fanning the Flames R. J. Davenport.
Telomerase aggravates oxidative damage in mitochondria.
[Abstract] [Full Text]

1 October 2004

Ras: The Other Pro-Aging Pathway V. D. Longo.
Might Ras play a role in aging in mammals as well as in yeast?
[Abstract] [Full Text]

Knife Jugglers R. J. Davenport.
Painkillers shift Alzheimer's protein slicer.
[Abstract] [Full Text]

Off With Your (Fork)Head M. Leslie.
One stress-defusing pathway shuts down another.
[Abstract] [Full Text]

24 September 2004

Brown Norway Rat D. J. Holmes.
This strain is used extensively in studies involving autoimmune diseases.
[Abstract] [Full Text]

Acid Trip R. J. Davenport.
Blocking pH-sensitive calcium channels prevents stroke damage.
[Abstract] [Full Text]

Yin and Yang M. Leslie.
Inflammatory molecules fight and foster atherosclerosis.
[Abstract] [Full Text]

17 September 2004

A Century of Population Aging in Germany E. Hoffmann and S. Menning.
How old is Germany?
[Abstract] [Full Text]

Tarnished Vision R. J. Davenport.
Iron glut clouds eyes in mice.
[Abstract] [Full Text]

Fatal Distraction M. Beckman.
Disciplining misshapen proteins leaves cells vulnerable to oxidative stress and death.
[Abstract] [Full Text]

10 September 2004

TOR Pathway: Linking Nutrient Sensing to Life Span P. Kapahi and B. Zid.
Pathway provides clues to the mechanism of life-span extension by dietary restriction.
[Abstract] [Full Text]

Will a Filet a Day Keep the Neurologist Away? M. Leslie.
Fish oil molecule forestalls neuron damage in Alzheimer's mice.
[Abstract] [Full Text]

Leashing Leishmania R. J. Davenport.
Some old mice fight parasitic infection better than young mice do.
[Abstract] [Full Text]

3 September 2004

Aging of the Human Adrenal Cortex P. J. Hornsby.
Cell loss and compensatory overgrowth might cause age-related changes.
[Abstract] [Full Text] [PDF]

Not Wisely but Too Well: Aging as a Cost of Neuroendocrine Activity C. V. Mobbs.
Does neuroendocrine activity accelerate aging?
[Abstract] [Full Text]

Osteoarthritis N. Shakoor and R. F. Loeser.
A case study.
[Abstract] [Full Text]

Regnerating Regeneration R. J. Davenport.
Classic models illuminate possible ways to rejuvenate human tissues.
[Abstract] [Full Text] [PDF]

D�j� Vu I. Chen.
Arguments in the stem cell debate mirror the controversy surrounding the first test tube baby.
[Abstract] [Full Text] [PDF]

Stuck in the Craw M. Leslie.
Parkinson's proteins choke cell's recycling system.
[Abstract] [Full Text]

Hastening Death to Delay Aging R. J. Davenport.
New approach speeds hunt for manipulations that retard fly decrepitude.
[Abstract] [Full Text]

27 August 2004

Longevity Is Infectious R. J. Davenport.
Bacteria foster long life in young flies.
[Abstract] [Full Text]

Going the Extra Mile R. J. Davenport.
Molecular manipulations turn ordinary mice into athletic stars.
[Abstract] [Full Text]

20 August 2004

Rtel–/– Mice M. Russell.
The Rtel gene encodes a helicase-like protein that functions in the regulation of telomere length.
[Full Text]

Membranes of Death M. Leslie.
Molecule prevents suicide triggered by cell's protein factories.
[Abstract] [Full Text]

Hardy Helper R. J. Davenport.
Molecular partner urges worm protein to trigger survival pathway.
[Abstract] [Full Text]

13 August 2004

Ticking Fast or Ticking Slow, Through Shc Must You Go? F. M. Martin and J. S. Friedman.
The adapter protein p66shc might integrate signals from several pathways to influence life span.
[Abstract] [Full Text]

Fast Burn M. Leslie.
Genetic modification that turns fat cells into furnaces extends longevity in mice.
[Abstract] [Full Text]

Eating Yourself to Life R. J. Davenport.
Signaling mechanisms that delay death induce starvation response in fruit flies.
[Abstract] [Full Text]

Trouncing Tau M. Beckman.
Mouse vaccine that neutralizes one Alzheimer's protein also eliminates another.
[Abstract] [Full Text]

6 August 2004

Murine Models of Life Span Extension J. K. Quarrie and K. T. Riabowol.
What can mice with defects in specific signaling molecules tell us about mammalian aging?
[Abstract] [Full Text]

Suppressed RAGE M. Leslie.
Cell-surface receptor battles compounds that promote aging by thwarting its alter ego.
[Abstract] [Full Text]

The Thing That Wouldn't Leave R. J. Davenport.
Immune cells that flock to fat-laden blood vessels stay when they should go.
[Abstract] [Full Text]

30 July 2004

Growing Pains R. J. Davenport.
As researchers sort through the hype surrounding growth hormone, they hope to uncover the molecule's actual benefits.
[Abstract] [Full Text]

Progressive Supranuclear Palsy M. Pourfar and J.-P. Vonsattel.
An uncommon disorder has many features similar to those of Parkinson's disease.
[Abstract] [Full Text]

High Anxiety M. Leslie.
Youthful stress impairs adult brain's ability to mint new cells.
[Abstract] [Full Text]

(Data)base Desires R. J. Davenport.
New resource compiles genes that potentially influence human aging.
[Abstract] [Full Text]

23 July 2004

Aging Cartilage and Osteoarthritis--What's the Link? R. F. Loeser Jr.
Low cell turnover, reduced growth factor signaling, and oxidative stress might contribute to this condition.
[Abstract] [Full Text]

Wising Up to Diabetes M. Leslie.
Insulin activity in brain and liver collaborate to prevent the metabolic disease.
[Abstract] [Full Text]

16 July 2004

Sex-Specific Effects of Interventions That Extend Fly Life Span J. M. S. Burger and D. E. L. Promislow.
Few studies measure the effects of manipulations on male versus female life span.
[Abstract] [Full Text]

Opposites Detract M. Leslie.
Hunger hormone quenches inflammation, opposing leptin.
[Abstract] [Full Text]

Long in the Tooth R. J. Davenport.
Paleolithic hominids outlived their predecessors, dental wear suggests.
[Abstract] [Full Text]

Resveratrol to the Rescue M. Leslie.
Compound that boosts yeast longevity also benefits worms and flies.
[Abstract] [Full Text]

9 July 2004

Immunotherapy for Alzheimer's Disease P. L. McGeer and E. McGeer.
Can a vaccine thwart this neurodegenerative disorder?
[Abstract] [Full Text]

All Pain, No Gain M. Leslie.
Shots in the elderly often miss their target, but researchers are starting to learn why.
[Abstract] [Full Text]

A Twist in an Early End R. J. Davenport.
Snafus in telomere unwinding foster a premature aging syndrome.
[Abstract] [Full Text]

Spiraling Toward Death M. Beckman.
Swirly mitochondria are associated with flies' demise.
[Abstract] [Full Text]

2 July 2004

Epigenetic Regulation of Aging in Honeybee Workers S. W. Omholt and G. V. Amdam.
Vitellogenin concentrations regulate life span in honeybees.
[Abstract] [Full Text]

Taking the Long View C. Aschwanden.
Studies that track people for decades have revealed tantalizing clues about the aging process that might otherwise lie undetected.
[Abstract] [Full Text]

Unraveling Socs M. Leslie.
Protein might block body's response to fat-reducing hormone.
[Abstract] [Full Text]

25 June 2004

S.W.A.T.-SOD Weapons and Tactics J. N. Sampayo and G. J. Lithgow.
Superoxide dismutase 1 is activated at the posttranslational level.
[Abstract] [Full Text]

Racing Against Time I. Chen.
Leslie Gordon was set for a career in pediatric ophthalmology until her son was diagnosed with a rare illness that mimics aspects of aging.
[Abstract] [Full Text]

Low-Cal Connections M. Beckman.
Calorie restriction might harness life-span extension protein to stop cell suicide.
[Abstract] [Full Text]

Stem Cell Savior M. Leslie.
Compound shelters neuron precursors during Parkinson's disease treatment.
[Abstract] [Full Text]

18 June 2004

Obesity Over the Life Course T. Mizuno, I-W. Shu, H. Makimura, C. Mobbs.
For the first time in modern history, the life expectancy of people in developed societies might begin to decrease.
[Abstract] [Full Text]

On Trial R. J. Davenport.
Jumping from laboratory to human studies puts researchers to the test.
[Abstract] [Full Text]

Too Much of a Good Thing R. J. Davenport.
Extra doses of antioxidant protein spur insulin resistance.
[Abstract] [Full Text]

11 June 2004

Inside Insulin Signaling, Communication Is Key to Long Life A. Antebi.
Activation of dFOXO in fat increases fly longevity.
[Abstract] [Full Text]

Neurodegeneration in Normal Brain Aging and Disease D. R. Thal, K. Del Tredici, H. Braak.
Activation of dFOXO in fat increases fly longevity.
[Abstract] [Full Text]

4 June 2004

Breaking in a New Function for Casein Kinase 2 J. C. Morales and P. B. Carpenter.
Enzyme plays a role in the repair of single-stranded DNA breaks.
[Abstract] [Full Text]

Counterattack E. Landhuis.
By squelching a fat-storage pathway, protein might connect diet with extended life.
[Abstract] [Full Text]

Peer Pressure R. J. Davenport.
Clustering sways antioxidant enzyme toward new behavior.
[Abstract] [Full Text]

28 May 2004

Declining Immunity with Age in the Wild D. Holmes and S. Austad.
Recent studies of wild bird populations provide evidence of immune senescence.
[Abstract] [Full Text]

GEHA--The Pan-European "Genetics of Healthy Aging" Project A. Nebel and S. Schreiber.
Consortium seeks to identify genes that promote long life and good health.
[Abstract] [Full Text]

A Life of Fusion I. Chen.
Olivia Pereira-Smith came from India, learned American science, and forged a lifelong research partnership studying cell aging.
[Abstract] [Full Text]

Symphony of Errors E. Landhuis.
Sloppy proofreading of mitochondrial DNA spurs a premature demise.
[Abstract] [Full Text]

Merging Routes R. J. Davenport.
Multiple paths lead to senescence.
[Abstract] [Full Text]

21 May 2004

Early Life Predictors of Old-Age Life Expectancy B. A. Rikke.
Combined measures of T cell subsets, body weight, and hormone concentrations in young mice predict life span.
[Abstract] [Full Text]

Shining a Light on Long Life M. Leslie.
Scientists identify key step in fruit fly longevity pathway.
[Abstract] [Full Text]

Anxious Aging M. Beckman.
Oxidatively stressed and old flies turn on many similar genes.
[Abstract] [Full Text]

14 May 2004

Vital Connections S. D. Pletcher.
Network analyses yield insights into the genetic mechanisms of aging.
[Abstract] [Full Text]

The Ageless Question--What Accounts for Age-Related Cognitive Decline? A. Nagahara and M. H. Tuszynski.
New results implicate a specific region of the hippocampus.
[Abstract] [Full Text]

Learning Is in the Blood M. Leslie.
Weakening the immune system saps brainpower.
[Abstract] [Full Text]

Calorie Restriction Un-SIR-tainty R. J. Davenport.
Yeast don't need SIR2 to starve their way to long life.
[Abstract] [Full Text]

Slipshod Survival M. Beckman.
Mice that produce energy inefficiently live longer than those that don't.
[Abstract] [Full Text]

7 May 2004

Come One, Come All S. S. Lee.
Gene expression profiles of individual aging nematodes differ from those of a synchronized worm population.
[Abstract] [Full Text]

Slacking Off E. Landhuis.
DNA-break repair pathway poops out in older cells.
[Abstract] [Full Text]

If Telomeres Thrive, You Will Survive M. Leslie.
Augmenting chromosome caps extends worm life span.
[Abstract] [Full Text]

30 April 2004

Methods for Genetic Dissection of Complex Traits T. F. C. Mackay.
The author responds to a recent SAGE KE Perspective on quantitative trait loci mapping studies.
[Abstract] [Full Text]

Many Roads to Ruin M. Leslie.
Aging undermines different tissues and organs in different ways. Understanding how might help us stay healthy longer.
[Abstract] [Full Text]

From Womb the Bell Tolls R. J. Davenport.
Stressing a fetus creates health problems that persist into old age.
[Abstract] [Full Text]

Bad to the Bone M. Leslie.
Proteins that build skeletons in embryos promote bone loss in the aged.
[Abstract] [Full Text]

23 April 2004

Physiological Complexity, Aging, and the Path to Frailty L. A. Lipsitz.
The fractal nature of physiological processes declines with age.
[Abstract] [Full Text]

Lethal Leak R. J. Davenport.
Protein that shortens mouse life span opens holes in mitochondria.
[Abstract] [Full Text]

Illegal Formation M. Leslie.
Stubby telomeres upset chromosome pairing in sperm and eggs.
[Abstract] [Full Text]

16 April 2004

A New Way to Lose Your Nerve A. I. Basbaum.
Bilateral loss of innervation can occur after unilateral nerve injury.
[Abstract] [Full Text]

Lightheaded M. Leslie.
Fat-produced hormone infiltrates the brain to slash weight.
[Abstract] [Full Text]

Fork in the Road R. J. Davenport.
Separate branches in insulin-related signaling pathway control worm hibernation and life span.
[Abstract] [Full Text]

Puzzling Out the Pieces E. Landhuis.
Dieting and dwarfism work together and separately at the molecular level to boost longevity.
[Abstract] [Full Text]

9 April 2004

Does Sex Age You? S. R. Proulx.
The dynamics of sexual encounters put a lower limit on life span.
[Abstract] [Full Text]

Hidden Talents M. Leslie.
Proteins implicated in Alzheimer's disease also coddle brain cells.
[Abstract] [Full Text]

More Without TOR M. Beckman.
Inhibiting nutrient sensor extends life span in fruit flies.
[Abstract] [Full Text]

Composed by Leptin M. Beckman.
Early in life, appetite hormone sets up circuitry that controls food intake during adulthood.
[Abstract] [Full Text]

Ercc1-/- Mice (Ercc1tm1Dwm Mice) J. Fuller.
ERCC1 functions in nucleotide excision repair and recombination repair.
[Full Text]

PARP-/- Mice J. Fuller.
PARP is an ADP-ribosyltransferase that functions in the posttranslational modification of nuclear proteins.
[Full Text]

2 April 2004

Werner Syndrome Protein--Unwinding Function to Explain Disease R. J. Monnat Jr. and Y. Saintigny.
Role in homologous recombination might be key to understanding cell defects.
[Abstract] [Full Text]

Wind at His Back I. Chen.
Trey Powers has been sailing at full speed into gerontology research since the age of 14.
[Abstract] [Full Text]

Never Too Old? M. Leslie.
Calorie-slashing diet might lengthen lives of even graying animals.
[Abstract] [Full Text]

26 March 2004

How Good Are Quantitative Complementation Tests? P. M. Service.
The search for life-span genes in Drosophila.
[Abstract] [Full Text]

The Flavor of Aging R. J. Davenport.
As researchers decipher why the ability to smell and taste deteriorates in the elderly, they hope to uncover ways to make aging more palatable.
[Abstract] [Full Text]

The Little RNAs That Could M. Leslie.
Midget RNA molecules trigger neuron maturation through unexpected mechanism.
[Abstract] [Full Text]

Preheating Primes Pruners M. Beckman.
Gentle warming charges up protein-chopping system in human skin cells.
[Abstract] [Full Text]

19 March 2004

Exploiting Proteomics in the Discovery of Drugs That Target Mitochondrial Oxidative Damage B. W. Gibson.
Is antioxidant therapy for aging a long way off or just around the corner?
[Abstract] [Full Text]

Androgens, ApoE, and Alzheimer's Disease J. Raber.
The various APOE alleles affect androgen signaling differently.
[Abstract] [Full Text]

Going Ku Ku on Bax M. Beckman.
Extrachemical affair shatters union, provokes suicide.
[Abstract] [Full Text]

Hop on Board R. J. Davenport.
Blueprint for fat-cell specialization hitches a ride from a shuttle protein.
[Abstract] [Full Text]

Greasing the Way for Bone Growth R. J. Davenport.
Signaling molecule steers cells toward bone and away from fat.
[Abstract] [Full Text]

Riddled With Errors S. Neeper.
Mutations mount in elderly sperm.
[Abstract] [Full Text]

12 March 2004

To Age or Not to Age--What Is the Question? T. Day.
A new model attempts to challenge old evolutionary theories.
[Abstract] [Full Text]

Can the Clock Be Turned Back on Ovarian Aging? P. B. Hoyer.
Findings suggest that mice make new eggs after birth.
[Abstract] [Full Text]

Sticking It to Tau M. Leslie.
Enzyme tags tau with deadly decorations.
[Abstract] [Full Text]

Throwing Fat on the Fire R. J. Davenport.
Mice lacking supposed insulin enabler are surprisingly lean.
[Abstract] [Full Text]

5 March 2004

Regulation of Transcriptional Coactivator PGC-1a D. Melloul and M. Stoffel.
Analysis of this metabolic regulator gives new insight into mechanisms of diabetes.
[Abstract] [Full Text]

Copper Stopper R. J. Davenport.
Obliterating a metal transporter immortalizes a fungus.
[Abstract] [Full Text]

All-or-None No More M. Leslie.
Brain cells mete out neurotransmitters.
[Abstract] [Full Text]

Tying It Together I. Chen.
Whether he's seeing elderly patients, crunching population data, or testing evolutionary theories of aging, Rudi Westendorp and his hallmark bow tie make a statement.
[Abstract] [Full Text]

27 February 2004

Is Akt the Mastermind Behind Age-Related Heart Disease? P. Kaminker.
The insulin/insulin-like growth factor pathway controls endothelial cell life span.
[Abstract] [Full Text]

Overcoming Inertia R. J. Davenport.
Inflammation gives neurons a shove when a cellular brake releases.
[Abstract] [Full Text]

Stop a Tumor, Save a Cell M. Leslie.
Cancer fighter helps cells survive lean times.
[Abstract] [Full Text]

20 February 2004

Impaired Angiogenesis in the Aged M. J. Reed and J. M. Edelberg.
New blood vessel creation impacts wound healing, vascular disease, and cancer.
[Abstract] [Full Text]

I Regret That I Have But One Life to Give for My Colony M. Leslie.
Aging yeast commit suicide to save neighbors.
[Abstract] [Full Text]

Augmenting With Amylin M. Beckman.
Hormone slows bone breakdown.
[Abstract] [Full Text]

13 February 2004

Search for Methuselah Genes Heats Up V. D. Longo.
Heat shock transcription factor 1 regulates stress resistance genes in selected tissues.
[Abstract] [Full Text]

Resistance Training M. Leslie.
Firing up the liver's fat metabolism staves off beginnings of diabetes.
[Abstract] [Full Text]

Cell Death, Start to Finish R. J. Davenport.
Nitric oxide and zinc cooperate to demolish overexcited neurons.
[Abstract] [Full Text]

Inbred Rodent Strain: CB6F1 Mouse J. M. Harper.
This mouse is a first-generation hybrid from a cross of a BALB/c female with a C57BL/6 male.
[Abstract] [Full Text]

Amyloid Precursor Protein (APP) Transgenic Mice (Tg2576 Mice) G. Zitnik.
Lipid peroxidation in the brains of young animals might foreshadow beta-amyloid deposition in the brains of old animals in this model of Alzheimer's disease.
[Full Text]

6 February 2004

From Genes to Societies O. Rueppell, G. V. Amdam, R. E. Page Jr., and J. R. Carey.
Social insects as models for research on aging.
[Abstract] [Full Text]

Inbred Rodent Strain: B6D2F1 Mouse J. M. Harper.
Longevity statistics were calculated with data from the National Center for Toxicological Research.
[Abstract] [Full Text]

30 January 2004

Frailty--The Search For Underlying Causes J. Walston.
Multiple pathways likely contribute to this syndrome.
[Abstract] [Full Text]

Hampering a Heartbreaker M. Leslie.
Antibiotics might stem injury from heart attack.
[Abstract] [Full Text]

When Spacing Out Brings Clarity R. S. Tuma.
Mental lapses serve as diagnostic clue for type of dementia.
[Abstract] [Full Text]

Plaque Attack R. J. Davenport.
Mice without ApoE and related protein unexpectedly accumulate b-amyloid deposits.
[Abstract] [Full Text]

23 January 2004

Dear Old Dad R. L. Glaser and E. W. Jabs.
Paternal age and the origin of spontaneous mutations in humans.
[Abstract] [Full Text]

Getting Connected M. Leslie.
Protein unexpectedly spurs brain cells to branch.
[Abstract] [Full Text]

Lipid-Control Allies S. Neeper.
New artery-cleaning agents might provide statin backup.
[Abstract] [Full Text]

16 January 2004

Glycation Stimulates Amyloid Formation M. E. Obrenovich and V. M. Monnier.
Recent research offers new clues into the etiology of "conformational" diseases.
[Abstract] [Full Text]

Vintage Gerontology I. Chen.
Judith Campisi, former folksinger and current wine buff, harvests knowledge from aging cells.
[Abstract] [Full Text]

b Amyloid's Accomplice? M. Leslie.
Molecular hit man might help Alzheimer's protein take out brain's white matter.
[Abstract] [Full Text]

Skeleton Key R. J. Davenport.
Lipid-processing enzyme weakens bones.
[Abstract] [Full Text]

9 January 2004

Maintaining Your Immune System--One Method for Enhanced Longevity E. Wollscheid-Lengeling, R.-J. M�ller, R. Balling, and K. Schughart.
Aging immune cells display spoiled cytokine circuits.
[Abstract] [Full Text]

There's a Problem in the Furnace J. Tower.
Superoxide dismutase mutation in the fly raises mitochondrial mayhem.
[Abstract] [Full Text]

Tasting Longevity M. Leslie.
Worms live longer after losing neurons for smell and taste.
[Abstract] [Full Text]

UnSIRtainty Principle R. J. Davenport.
Conflicting results underscore questions about how calorie restriction activates yeast longevity enzyme.
[Abstract] [Full Text]

Picky Eater R. J. Davenport.
Gluttonous cellular recycler hungers for damaged proteins.
[Abstract] [Full Text]

2 January 2004

Classic Papers
PDFs of historical (pre-1990) articles on aging.

Genetically Altered Mice
Summaries of essential information on critters created in the lab.

Catalase and Mouse M. Leslie.
Enzyme-enhanced rodents scurry longer.
[Abstract] [Full Text]

TORquing Toxins R. J. Davenport.
Extra doses of movement-disorder protein guard neurons against poisons.
[Abstract] [Full Text]

Weak of Body, Weak of Mind? M. Leslie.
Dwindling testosterone concentrations in elderly men increase risk of Alzheimer's disease.
[Abstract] [Full Text]

19 December 2003

Cyclin-Dependent Kinase 5--A Neuronal Killer? Q. Guo.
New findings connect b-amyloid toxicity and tau hyperphosphorylation.
[Abstract] [Full Text]

Power to the People R. J. Davenport.
Move over, worms, flies, and mice. Humans have glitches in insulin-related signaling pathways too.
[Abstract] [Full Text]

Aging by Numbers T. B. L. Kirkwood.
A review of Longevity: The Biology and Demography of Life Span by James Carey.
[Full Text]

Out, Out, Damned Zinc M. Leslie.
Metal-grabbing antibiotic might hinder Alzheimer's disease.
[Abstract] [Full Text]

Fear Factor R. J. Davenport.
Timid mice die sooner than more adventurous siblings.
[Abstract] [Full Text]

12 December 2003

Can New Neurons Replace Memories Lost? T. J. Shors.
Alzheimer's disease brains exhibit new neuron growth.
[Abstract] [Full Text]

Battle Scars M. Leslie.
Cells in the elderly immune system remember old skirmishes but not recent ones.
[Abstract] [Full Text]

What's That Smell? R. J. Davenport.
Aging flies lose middle-term memory.
[Abstract] [Full Text]

Mission (Not) Impossible I. Chen.
Nir Barzilai's service in the Israeli Defense Forces provided superb training for his subsequent life as a scientist.
[Abstract] [Full Text]

5 December 2003

Does the Road to Muscle Rejuvenation Go Through Notch? J. B. Miller and C. P. Emerson Jr.
Findings offer insight into the effect of aging on muscle repair.
[Abstract] [Full Text]

Coronary Artery Disease and the MEF2A Transcription Factor E. N. Olson.
A human pedigree reveals a relation between heart disease and a well-studied regulatory protein.
[Abstract] [Full Text]

Just a Little Bit R. J. Davenport.
A pinch of growth hormone gives young rats an old collection of drug-processing enzymes.
[Abstract] [Full Text]

Dense Matter M. Beckman.
Compact bones can still break easily.
[Abstract] [Full Text]

28 November 2003

Linking Development and Aging B. J. Zwaan.
Food deprivation during Drosophila larval development reduces fertility but not life span.
[Abstract] [Full Text]

Rising Expectations M. Leslie.
Living for a century could be commonplace by 2100 if some projections of life expectancy are right--but are they?
[Abstract] [Full Text]

Eat Less, Nurture Neurons R. J. Davenport.
Cutting calories curbs production of brain-disabling protein as well as Alzheimer's plaques.
[Abstract] [Full Text]

21 November 2003

Sarcopenia--A Critical Perspective R. T. Hepple.
Researchers rethink current conjectures about muscle wasting in the aged.
[Abstract] [Full Text]

Consequence, Not Cause R. J. Davenport.
Oxidants arise from, but aren't required for, lethal neuron overstimulation.
[Abstract] [Full Text]

Whodunit? R. J. Davenport.
Product of neuron-damaging enzyme cleared of wrongdoing.
[Abstract] [Full Text]

Visceral Reaction M. Leslie.
A nematode's intestine, not just its neurons, dictates its aging rate.
[Abstract] [Full Text]

The "Fly Die" Diet M. Beckman.
Coenzyme Q-less banquet that prolongs worm lives doesn't work for fruit flies.
[Abstract] [Full Text]

14 November 2003

On the Memory of a Chronic Illness P. J. Goldschmidt-Clermont and E. D. Peterson.
Research on progenitor cells illuminates the causes of and potential cures for age-related diseases.
[Abstract] [Full Text]

The Many Ways of Forgetting M. Leslie.
Sharpening long-term memory in the elderly might blur their short-term recall.
[Abstract] [Full Text]

Centenarian Advantage M. Beckman.
Gene that assembles "bad cholesterol" particles influences human life span.
[Abstract] [Full Text]

Brain Lubricant R. J. Davenport.
Antiatherosclerosis protein helps brain cells shuttle cholesterol carrier.
[Abstract] [Full Text]

7 November 2003

Strategies for Engineered Negligible Senescence D. A. Gray.
Meeting explores whether the ability to slow aging is in the foreseeable future.
[Abstract] [Full Text]

Inbred Rodent Strain: DBA/2 Mouse D. J. Holmes.
This inbred laboratory mouse strain was started around 1930.
[Abstract] [Full Text]

JNK-ing Cellular Poisons M. Leslie.
Embryo-shaping genetic pathway stanches oxidation.
[Abstract] [Full Text]

Crypt-ic Message R. John Davenport.
Stem cells in the gut pile up mutations in mitochondrial DNA.
[Abstract] [Full Text]

31 October 2003

Huntington's Disease M. Groves, J.-P. Vonsattel, P. Mazzoni, and K. Marder.
A case study.
[Abstract] [Full Text]

Detangling Alzheimer's Disease L. Helmuth.
Toward better diagnostics and possible therapeutics.
[Abstract] [Full Text]

Apolipoprotein E4 Mice J. Fuller.
Mice that carry the human apoE4 gene display impairments in learning, memory, and exploratory behavior.
[Full Text]

Guinness-Bound M. Beckman.
Mutated, manipulated worms set nematode life-span record.
[Abstract] [Full Text]

Wrinkle Treatment for Worms C. Seydel.
Drugs appear to squelch life-shortening oxygen compounds in nematodes.
[Abstract] [Full Text]

24 October 2003

Research on the Brain V. M.-Y. Lee and J. Q. Trojanowski.
Recent meeting highlights paradigm shift in our understanding of a-synucleinopathies.
[Abstract] [Full Text]

Eyes Wide Open I. Chen.
What academic scientists need to consider before diving into biotech--the good, the bad, and the ugly.
[Abstract] [Full Text]

Bone Surprise R. J. Davenport.
Hormone reveals unexpected skeleton-bolstering power.
[Abstract] [Full Text]

Quench a Burning Heart M. Leslie.
Cardiac protein stanches inflammation and stymies heart failure.
[Abstract] [Full Text]

17 October 2003

Greasing Aging's Downward Slide N. Ross-Flanigan.
Shifts in lipid profiles over time predispose people to heart disease, diabetes, and dementia--and might hasten the fundamental process of aging.
[Abstract] [Full Text]

Phosphate Fast R. J. Davenport.
Denying a chemical change to a fat-cell protein keeps metabolism healthy.

Common Denominator M. Beckman.
One protein connects three routes by which diabetes ravages hearts.

10 October 2003

Reducing Integrins Improves the Quality of Fly Life C. N. Torgler and N. H. Brown.
Old mys mutant flies climb higher.
[Abstract] [Full Text]

Maturity Mimic M. Beckman.
WRN-defective cells and old cells switch same genes on and off.

Taking a Tumble R. J. Davenport.
Lung protein flips to stimulate, rather than block, inflammation.

Portrait of DNA's Protector M. Leslie.
Researchers take first close-up of protein that stabilizes chromosomes.

3 October 2003

Ceramide, Stress, and a "LAG" in Aging L. M. Obeid and Y. A. Hannun.
Connections have emerged between ceramide and organismal aging.
[Abstract] [Full Text]

Plaques Aglow M. Leslie.
Amyloid-loving molecule could furnish the first diagnostic test for Alzheimer's disease.

Messmaker R. J. Davenport.
Enzyme creates garbage backup that's linked to Alzheimer's disease.

26 September 2003

Mitotic and Postmitotic Senescence in Plants S. Gan.
A fresh crop of results increases our understanding at the molecular level.
[Abstract] [Full Text]

Weathering the HRT Storm T. M. Powledge.
Despite a torrent of negative studies on hormone replacement therapy, significant questions remain.
[Abstract] [Full Text]

Trouble Starts Within R. J. Davenport.
Mitochondria's poisons destabilize the nuclear genome.

Second Chance M. Beckman.
Starting at any age, eating less extends fruit fly longevity.

19 September 2003

How Does the Huntington's Disease Mutation Damage Cells? D. C. Rubinsztein.
Mutation has myriad effects on cell physiology.
[Abstract] [Full Text]

Ups and Downs C. Seydel.
The brain retains its complexity, even in old age.

Barking up the Tree of Long Life M. Beckman.
Dogs give rate-of-living hypothesis the cold nose.

Live Fast, Die Old? M. Leslie.
Flies don't have to slow down to last.

12 September 2003

Autophagy and Aging--When "All You Can Eat" Is Yourself A. M. Cuervo.
Worm provides insights into life span, stress, and recycling cellular components.
[Abstract] [Full Text]

Focusing on the Big Picture I. Chen.
Neurobiologist and photographer Adam Gazzaley uses different lenses to view brain aging and the natural world.
[Abstract] [Full Text]

Rusty Hatches M. Beckman.
Jammed mitochondrial portals in old cells lock out DNA fix-it protein.

Starve a Neuron, Feed Pneumonia R. J. Davenport.
Mice reveal immune changes that might render stroke patients susceptible to infection.

Apoplectic From ApoE M. Leslie.
Protein abets b-amyloid buildup in brain's blood vessels.

F344 Rat D. J. Holmes.
This inbred rodent strain originated at Columbia University in 1920.

5 September 2003

Amyotrophic Lateral Sclerosis P. H. Gordon, H. Mitsumoto, and A. P. Hays.
A case study.
[Abstract] [Full Text]

Stimulated to Death M. Leslie.
Excess dopamine slays movement-controlling neurons in the brain.

29 August 2003

Ubiquitin, Proteasomes, and the Aging Brain D. A. Gray, M. Tsirigotis, and J. Woulfe.
Inefficient proteolysis might produce toxic inclusions in neurons and glial cells.
[Abstract] [Full Text]

The Mouse That Roared I. Chen.
Andrzej Bartke investigates aging in mouse varieties great and small.

Raise a Glass to Long Life M. Leslie.
Chemical in red wine uncorks longevity in yeast and human cells.

Small Groups, Big Trouble R. J. Davenport.
Soluble amyloid clumps that disrupt neuron connections amass in Alzheimer's brains.

22 August 2003

The Persistence of Senescence N. E. Sharpless.
Durability depends on the presence of p16.
[Abstract] [Full Text]

Trading Places R. J. Davenport.
Mitochondrial exchange makes dumb mice smarter and smart mice dumber.

Midlife Stasis M. Leslie.
Neurons grow less flexible with age.

Triple-Transgenic Alzheimer's Disease Model Mice G. Zitnik.
Studies of these mice support the amyloid cascade hypothesis for Alzheimer's disease pathology.

Estrogen, Bone, and Osteoporosis B. L. Riggs.
Presentation on sex hormones and age-related bone loss.

15 August 2003

Meeting Summary--Cell Biology of Parkinson's Disease and Related Neurodegenerative Disorders J. Q. Trojanowski and V. M.-Y. Lee.
New advances aid in the understanding of underlying mechanisms.
[Abstract] [Full Text]

Chasing 100 I. Chen.
Thomas Perls has been running after centenarians to learn what keeps them ticking.

Atypical Situation C. Mooney.
Two premature aging syndromes previously considered distinct turn out to be connected.

Stop and Go M. Beckman.
Protein that ravages mature neurons stimulates production of new ones.

Suffocating Aging R. J. Davenport.
New model proposes that age-retarding mutations make worms go anaerobic.

Making Mischief in Macrophages M. Leslie.
Fat-slicing enzyme spurs atherosclerosis in a novel way.

8 August 2003

Diverse Dealings of the Werner Helicase/Nuclease W.-H. Cheng and V. A. Bohr.
WRN may promote precise DNA repair through a structural role.
[Abstract] [Full Text]

Second Chance E. Kintisch.
Souped-up thyroid hormone might make good as obesity treatment.

Evolutionary Oxymoron M. Beckman.
Sperm development encourages mutations that harm offspring.

1 August 2003

Mouse and Human Cells Versus Oxygen P. J. Hornsby.
Human cells display enhanced ability to limit oxidative damage.
[Abstract] [Full Text]

Fatal Stability M. Leslie.
Tau might kill neurons by tampering with the cellular skeleton.

Plugging the Memory Drain R. J. Davenport.
Blocking transport protein improves learning in old mice.

A Keen I M. Beckman.
Razor-sharp molecular method mucks up miscreant gene without vandalizing helpful one.

25 July 2003

The Molecular Basis of Age-Related Kidney Disease F. Zheng, A. R. Plati, A. Banerjee, S. Elliot, L. J. Striker, and G. E. Striker.
Glomerular progenitor cells from normal mice reverse renal disease.
[Abstract] [Full Text]

Advanced Sell Technology
Chris Mooney reviews Merchants of Immortality, by Stephen S. Hall.

Funded Up and Raring to Go I. Chen.
The American Federation for Aging Research is giving away more than $7 million in biogerontology grants in 2003, and its awardees have nifty plans for spending it.

Invest in the Future, Invest in Yourself R. J. Davenport.
Model adds nurturing factor to evolutionary theory of aging.

The Manly Route to Strong Bones M. Leslie.
Testosterone is tough enough to build the skeleton without an estrogen go-between.

18 July 2003

The Quest for a General Theory of Aging and Longevity L. A. Gavrilov and N. S. Gavrilova.
Reliability theory might explain aspects of aging.
[Abstract] [Full Text]

Plugging a Deadly Leak M. Leslie.
Mitochondrial protein fortifies the brain against stroke.

Foxo Ladies Squander Their Eggs C. Seydel.
Gene might link aging with early ovarian failure in mice.

11 July 2003

Caloric Restriction in trans B. S. Kristal and U. Paolucci.
Tissue culture model dishes up new ways to study dietary restriction.
[Abstract] [Full Text]

Cancer or Aging, Take Your Pick R. J. Davenport.
Protein that keeps aging on pace might help oncogene do its dirty work.

Bad Seeds M. Leslie.
Mutation that exacerbates Huntington's disease can appear even before sperm generation.

4 July 2003

Adult Cardiac Stem Cells--Where Do We Go from Here? J. M. Edelberg, M. Xaymardan, S. Rafii, and M. K. Hong.
Studies hint at promise for the treatment of heart disease.

The Future of Human Longevity--How Important Are Markets and Innovation? J. W. Vaupel.
Evidence suggests that life expectancy is not approaching its limit.

Science on the Fly. I. Chen.
Former bike racer and high school teacher Marc Tatar almost walked away from a career in the evolutionary biology of aging.

Talkin' 'Bout Regeneration. M. Leslie.
Researchers finger muscle-making cells.

Ouch! R. J. Davenport.
Glycine puts extra hurt into pain neurons.

27 June 2003

Does Anti-Aging Equal Anti-Microbial? G. J. Lithgow.
Long-lived worms resist bacterial pathogens.

Growing Old, Bacterial Style. M. Leslie.
Will bacteria tell us how to build a tougher human cell?

Inbred Rodent Strain: B6C3F1 Mouse. J. M. Harper.
This mouse is a first-generation hybrid strain produced by crossing C57BL/6 females and C3H males.

You Must Remember This. M. Leslie.
Experimental compounds curtail age-linked memory loss and prevent brain oxidation in rodents.

Trashing a Longevity-Slasher. R. J. Davenport.
p53 partner disposes of a protein that promotes aging.

20 June 2003

Urine-Concentrating Ability in the Aging Kidney. J. M. Sands.
Cloning of medullary transport proteins has facilitated molecular studies.

Renaissance Woman. I. Chen.
Nadia Rosenthal stretches her muscles as head of EMBL's mouse research center near Rome.

Keeping Out the Riffraff. M. Leslie.
New strategy might lock Alzheimer's protein out of the brain.

Good Timing. C. Seydel.
Defects in two proteins leave the body's clock vulnerable to age-related breakdown.

13 June 2003

Monitoring Proteins in Intact Cells. O. Berezovska, B. J. Bacskai, and B. T. Hyman.
Advanced microscopy methods yield insight into neurodegeneration and aging.

Immunity Challenge. R. J. Davenport.
The immune system falters with age, and researchers are beginning to understand why.

No Small Advantage. M. Leslie.
Diminutive mice don't necessarily gain extra time.

Coming Into Focus. R. J. Davenport.
New lens-regeneration secrets might improve cataract treatment.

Rewarding Research. C. Seydel.
New prize aims to stimulate antiaging discoveries.

6 June 2003

Creating New Neurons in Old Brains. P. M. Wise.
Growth factors stimulate neurogenesis in aged mice.

Durable Dwarves. R. J. Davenport.
Stress-resistant cells come in small packages.

Intervention Venture. M. Beckman.
New program will scrutinize potential methods for life span extension.

Lost Without a LIM. R. J. Davenport.
Protein drives cells to wounds.

30 May 2003

Great Expectations. I. Chen.
Florian Muller is determined to figure out how free radicals contribute to aging.

Mommy Tastiest. M. Leslie.
Mother-eating offspring might shape sex differences in worm longevity.

Youthful Infusion. C. Seydel.
Young ovaries rejuvenate old mice.

Rise to Power. M. Beckman.
Known gene regulator turns out to play crucial role in building smooth muscle cells.

23 May 2003

Meeting Report--44th Annual Drosophila Research Conference. J. Cypser.
Flying high with new results for aging-related research.

Old Livers Get a Complex. R. J. Davenport.
Newly discovered protein mélange might prevent old livers from regrowing.

Vital Collaboration. M. Beckman.
Cellular heat-protection system works with insulin-like pathway to bestow long life.

Open for Business. M. Beckman.
NIH study sections devoted to the biology of aging are ready to take grant applications.

16 May 2003

Telomerase and the Aging Heart. E. K. Heist, F. Huq, and R. Hajjar.
Can maintenance of chromosome ends help the brokenhearted?

The Networker. I. Chen.
Brian Clark loves brainstorming on scientific collaborations at conferences. But don't keep him from catching Liverpool's latest soccer match.

Everything in Moderation. M. Leslie.
New approach might soothe a side effect of Parkinson's disease treatment.

Reduced Renewal. R. J. Davenport.
Meager stem cell cache thins bones in mutant mice.

9 May 2003

Defects in Dynein Linked to Motor Neuron Degeneration in Mice. J. Andersen.
Implications for human disease.

Hear Today, Gone Tomorrow. M. Beckman.
Growth brake protects sound-receiving neurons.

Chip off the Old Brain. M. Leslie.
Memory-robbing brain changes begin in youth.

Hungering for Simplicity. E. Strauss.
Calorie restriction activates stress-based longevity pathway.

2 May 2003

Direct and Indirect Transcriptional Targets of DAF-16. P. L. Larsen.
Gene expression analyses provide new pieces for, but do not solve, the life span puzzle.

The Accidental Biologist. I. Chen.
Eugenia Wang picked up tips for running her lab by reading the biographies of military leaders.

Go or No-Go? R. J. Davenport.
Mixed results complicate hopes for nerve regeneration.

Less Mucus, More Bone. M. Beckman.
Allergy provoker thins skeleton.

25 April 2003

Is DNA Cut Out for a Long Life? D. Sinclair.
The jury is still out on the DNA damage hypothesis.

Mitochondrial Mayhem. R. J. Davenport.
Alzheimer's protein disarms the cell's energy plant.

Lamin-tation. R. J. Davenport.
Newly discovered mutation underlies rare premature aging disease.

Join the SAGEMAIL Discussion Group.
Share information and opinions about aging-related topics.

18 April 2003

Losing StAR Power. M. Beckman.
Oxidants thwart testosterone production by barring crucial transporter from mitochondria.

Parkinson's Shake-Up. M. Leslie.
Common anti-inflammatory drugs might spare brain cells of patients through unanticipated mechanism.

Foundations of Longevity. R. J. Davenport.
Genome search turns up targets of life-extending worm protein.

11 April 2003

The Constantly Changing Face of Chromatin. A. Vaquero, A. Loyola, and D. Reinberg.
A plethora of proteins promote regulation by chromatin structure.

All That Jazz. I. Chen.
Saxophone or microscope? Worm geneticist Adam Antebi handles both instruments with flair.

Your Intestines or Your Life. M. Leslie.
Inflammation-producing protein saves suicidal cells but provokes organ failure.

Spark of Life. R. J. Davenport.
Mutation in worm insulin-like gene kindles longevity pathway.

4 April 2003

Frontotemporal Dementia. L. S. Honig, K. Bell and S. S. Chin.
A case study.

Settle Down! M. Leslie.
Alzheimer's protein might calm rambunctious neurons.

Good Housekeeping. C. Seydel.
Staying junk-free helps worms live longer.

28 March 2003

Help Available--Phenomenological Models for Research on Aging. A. Mitnitski and K. Rockwood.
Physicists suggest a mathematical approach to deciphering the aging process.

Mindful of Metal. M. Leslie.
Researchers have exonerated aluminum pans as the cause of Alzheimer's disease; Ashley Bush has built a case against other forms of metals.

SAGA of Dying Neurons. R. J. Davenport.
Disease-causing protein blocks histone modification.

Out-of-Sync Cycle. M. Beckman.
Mistimed fertility hormone in older women spurs premature ovulation.

Senescence Tip-Off. R. J. Davenport.
Tacky telomere ends erode as cells age.

Turn Off the Iron. K. Ramsayer.
Impounding the metal might thwart Parkinson's disease progression.

21 March 2003

g-Secretase--Intramembrane Protease with a Complex. M. S. Wolfe.
Enzyme acts from womb to tomb, embryogenesis to Alzheimer's.

Double Duty. M. Beckman.
Insulin-chomping protein might couple diabetes and Alzheimer's disease.

Rescue Code. R. J. Davenport.
DNA repair might depend on patterns of histone modifications.

Decorated for Death. M. Leslie.
Tagging DNA-silencing protein trims survival in high-living yeast.

14 March 2003

Vitamin B1 Blocks Damage Caused by Hyperglycemia. M. E. Obrenovich and V. M. Monnier.
Will thiamine offer a simple solution to complications of diabetes?

Death Be Not Degrading. R. J. Davenport.
Parkinson's protein trashes cell-suicide protein to block neuron death.

Extra CRISPy, Please. C. Seydel.
Hormone candidate staves off stress and helps worms live longer.

Shooting for the Stars. I. Chen.
When Bridget Williams isn't investigating how cells keep telomeres in check, she's urging fellow students forward on their scientific trajectories.

Classic Papers: Seminal Literature.
Download PDFs of historical (pre-1990) articles on aging.

7 March 2003

Unearthing Loci That Influence Life Span. M. Tatar.
Steroid hormones and their receptors regulate longevity in Drosophila.

Clearance Cell. R. J. Davenport.
Astrocytes melt amyloid plaques.

Something for Almost Nothing. C. Seydel.
Longevity's price is negotiable.

Out of the Lab, Into the Legislature. K. Ramsayer.
New Web site focuses on policy implications of aging-related research.

Live Long and Ferment. M. Leslie.
Antioxidant enzyme helps yeast live to ripe old age.

28 February 2003

Functions of Eukaryotic DNA Polymerases. P. V. Shcherbakova, K. Bebenek, and T. A. Kunkel.
A repertoire of repair enzymes accurately replicates the genome.

Subfield History: Caloric Restriction, Slowing Aging, and Extending Life. E. J. Masoro.
Modified munching enhances mammalian maximal life-span.

Dietary Drawbacks. K. Hopkin.
Cutting calories doesn't guarantee long life and perfect health for all.

Germline Genomes--A Biological Fountain of Youth? C. A. Walter, R. B. Walter, and J. R. McCarrey.
Genomic instability occurs in female and male germ cells.

All in Your Mind. L. Helmuth.
Aging weakens some cognitive abilities but strengthens others.

Get Wild. R. J. Davenport.
Do the genetic rules of aging in the lab apply in less civilized conditions?

Genetically Altered Mice: Igf1r+/-, Telomerase RNA Component (Terc) Knockout, and p66Shc-/- Mice.
Mutant mice exhibit effects on life-span.

Gain on Pain. M. Beckman.
Scientists identify portion of molecule that relays pain from damaged nerves.

Protective Parents. R. J. Davenport.
Yeast moms bear brunt of protein damage.

21 February 2003

Stress for Success. M. Leslie.
A little hardship can do a body good.

Wake-Up Call. I. Chen.
Aubrey de Grey raises eyebrows by arguing that interventions that reverse aging could work in mice before the end of the decade.

Resistance Is Futile. M. Leslie.
Insulin resistance doesn't presage diabetes unless the illness runs in the family.

Bridge Inside Troubled Cells. M. Beckman.
Stress unites protective proteins by forming atomic ties.

14 February 2003

Subfield History: Use of Model Organisms in the Search for Human Aging Genes. H. R. Warner.
Worms, flies, and mice make a big impact on aging-related research.

Acing the Stress Test. K. Ramsayer.
Life-extending genetic alteration prevents artery damage.

Farewell to Fatherhood. M. Leslie.
In men, sperm vitality goes the way of the hairline and the taut stomach.

7 February 2003

Structure-(Dys)function Relationships in Mitochondrial Electron Transport Chain Complex II? B. S. Kristal and B. F. Krasnikov.
Why reactive oxygen species are usually not produced by succinate dehydrogenase.

When Tips Disappear, the End Is Near. R. J. Davenport.
Short telomeres presage mortality, but do they cause it?

Think Positive. C. Seydel.
New genome-wide search technique turns up genes that promote long life rather than curtail it.

Lasting Without Fasting. R. J. Davenport.
Zapping insulin signaling in fat helps well-fed mice persist.

Listening to the Song of Senescence. I. Chen.
Caleb Finch's work has been one riff after another on the theme of aging.

31 January 2003

The Contribution of Functional Brain Imaging to Our Understanding of Cognitive Aging. A. Gazzaley and M. D'Esposito.
New views yield clues to how the brain ages.

Unraveling Chromosome Chaos. M. Leslie.
Trimmed telomeres might provoke premature-aging disease.

From Cheeseburgers to Chest Pains. C. Seydel.
Receptor might help fat clog arteries.

Down But Not Out. M. Beckman.
Stripping chemical ornaments can reactivate cancer-thwarting gene.

Healing Power. C. Seydel.
Protein kick-starts skin's repair process.

24 January 2003

Alzheimer's Disease, Neuropeptides, Neuropeptidase, and Amyloid-b Peptide Metabolism. T. Saito, Y. Takaki, N. Iwata, J. Trojanowski, and T. C. Saido.
How aging prepares the brain for Alzheimer's disease.

Endless Drive. I. Chen.
Geneticist Vicki Lundblad charges full steam ahead in her studies of how chromosomes sustain their ends.

Century Mark. M. Leslie.
Unorthodox mitochondria might power extreme longevity.

Shear Benefits. M. Beckman.
Antioxidants and arginine cushion vessels from high-speed blood flow.

Joining Forces. R. J. Davenport.
Elixir, Centagenetix unite.

17 January 2003

Parc'n Brake. R. J. Davenport.
Relative of Parkinson's protein impounds p53 in the cytoplasm.

Overturned Ends. M. Beckman.
Ribosomes trump telomeres in premature-aging disease.

Casting Doubt. C. Seydel.
New results challenge antioxidant's life-extending capabilities.

10 January 2003

An Engineer's Approach to the Development of Real Anti-Aging Medicine. A. D. N. J. de Grey.
Mending age-related damage might boost healthy human life expectancy.

Hungry for Science. I. Chen.
Edward Masoro, whose pioneering research has probed how eating less can lengthen life-span, thrives on a diet rich in scientific exploration.

Ageless Quest. L. Guarente.
One scientist's search for genes that prolong youth.

No ALTernative. R. J. Davenport.
For hard-core cancer cells, only telomerase will do.

Seedy Weed. M. Beckman.
Extra longevity gene might boost plant fecundity.

Broken Barrow. M. Beckman.
Protein involved in neurodegenerative disease loses ability to deliver molecules.

3 January 2003

Meetings and Events Calendar.
Conferences and courses, with links to additional resources.

Genes/Interventions Database.
A collection of genes and interventions studied with respect to their effects on life-span, progeroid syndromes, or age-related neurological diseases.

Classic Papers.
PDFs of historical (pre-1990) articles on aging.

Genetically Altered Mice.
A catalog of genetically engineered mice used in aging-related research.

Aging in the Arts.
Depictions of aging in art and literature, from the classical to the contemporary.

20 December 2002

Wake Up and Smell the Maillard Reaction. V. M. Monnier and M. E. Obrenovich.
Do processed foods promote aging and age-related disease?

Lipid Peroxidation and the Aging Process. D. Praticò.
Damaged lipids might hasten decline.

The Burden of Pain on the Shoulders of Aging. M. Beckman.
When growing old hurts.

Rookie Rising. I. Chen.
Matt Kaeberlein went from first-year grad student to biotech exec in just 4 years.

Paper Chase. M. Leslie.
Novel database charts path through calorie-restriction literature.

13 December 2002

Titin--Springing Back to Youth? F. Huq, E. K. Heist, and R. J. Hajjar.
Largest known protein might play a role in heart function and failure.

One for All. R. J. Davenport.
Worm and fly longevity pathway controls mouse aging, too.

Molecular Immortality. M. Beckman.
Famous chromosome-protecting protein helps maintain master copy of DNA in stem cells.

Long Life Starts Early. K. Ramsayer.
Worms gain time by cutting energy production as larvae.

6 December 2002

Europe Wakes Up to Aging. G. Weiss.
Its nations have long neglected the science of aging--but change is in the air.

Ageless Activist. I. Chen.
Paola Timiras has advocated for education about aging since the '60s.

Domino Effect. C. Seydel.
Multiple DNA-wrapping proteins might execute calorie restriction's life-extending effects in fruit flies.

29 November 2002

Spotlight on Nematode Mitochondria in RNAi Mega-Screen. S. Melov.
Meddling with mitochondrial metabolism lengthens life.

Biologists Finally Horn In on Senescence in the Wild. C. C. Spencer and D. E. L. Promislow.
Antler flies offer angles on aging in a natural population.

Not in Medflies. T. S. May.
Calorie restriction doesn't increase longevity in all species.

22 November 2002

Perennially Young? K. Morgan.
Plants' capacity to renew spent parts thwarts aging, but our green cohabitants might not elude the process completely.

Having It All After All. R. J. Davenport.
p53 surplus staves off cancer but doesn't speed aging.

Lean, Yes--But Mean? R. J. Davenport.
Growth hormone thins and strengthens the elderly, but at a cost.

BAD Time for Suicide. M. Beckman.
Growth factors save cells by foiling mitochondrial disrupter.

15 November 2002

Error Catastrophe in Mutant Mitochondria . L. L. Mays Hoopes.
Inaccurate polymerase causes a progressive muscle disorder.

Metal for Mettle. M. Beckman.
Shortage of iron-containing molecule might contribute to Alzheimer's disease and aging.

Aging Takes Its Toll. R. J. Davenport.
Old immune systems lose first line of defense against invaders.

Head Rush. I. Chen.
Neuroendocrinologist William Sonntag grooves on growth hormone.

8 November 2002

Glutamate-Cysteine Ligase Modifier Knockout Mouse.
Tissues retain reduced amounts of glutathione, and cells show increased sensitivity to peroxide.

The Plot Thickens on Thin Bones. R. J. Davenport.
New discoveries offer promise for the development of bone-building osteoporosis drugs.

Dead Last. M. Leslie.
Study boosts hypothesis for why aging ceases in the very old.

Feed a Cell, Deprive an Organism? C. Seydel.
Life-shortening protein shuttles organic molecules across the cell membrane.

Winding Up to Wind Down. R. J. Davenport.
Dearth of DNA-loosening enzyme makes cells slumber.

1 November 2002

Of Worms, Flies, Dwarfs, and Things That Go Bump in the Night. W. E. Sonntag and M. M. Ramsey.
Insulin/IGF-1 signaling in the nematode influences life-span during adulthood but not during larval development.

Flies Like Us. M. Leslie.
Drosophila soars as a model for brain diseases.

Tissue-Tampering Turn-On. R. J. Davenport.
Protein activates senescence genes.

The Eyes Have It. C. Seydel.
A retina's own molecules might cause blinding disease.

25 October 2002

The Drifter. I. Chen.
A sinuous pathway has led Gary Ruvkun to probe how C. elegans grows old.

Liver-Specific IGF-1-Deficient Mice.
IGF-1 regulates growth and cell proliferation by inducting the phosphatidylinositol 3-kinase survival pathway.

Boundary War. M. Beckman.
Opposing enzymes establish border between active and silent DNA.

Deadly Giveaway. R. J. Davenport.
Protein linked to Parkinson's disease squanders clearance molecules.

18 October 2002

Mitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative Disease. O. Ogawa, X. Zhu, G. Perry, M. A. Smith.
Coenzyme Q10 delays disease progression in Parkinson's patients.

Losing Their Grip. R. J. Davenport.
Old immune cells let transgressors slip away.

All Fat Is Not Created Equal. M. Beckman.
Stomach surplus hinders rodents' ability to use glucose.

11 October 2002

Rules of Attraction. M. Leslie.
Wound-closing cells might initiate formation of artery-plugging plaques.

Tumor-Free, But Not in the Clear. R. J. Davenport.
Off-kilter tumor suppressor promotes aging and stunts growth.

4 October 2002

Setting a Trap for Aging-Related Genes in Drosophila. J. Tower.
Jumping gene zeroes in on potential biomarkers of aging.

RAINing on the RANK Parade. R. J. Davenport.
Newly identified protein blocks bone destruction.

27 September 2002

Closing the Generation Gap. M. Beckman.
Yeast moms that produce energy inefficiently bear old daughters.

Hanging Out. M. Beckman.
Freewheeling chromosome ends might signal old age.

Harlequin, a Genetically Altered Mouse. G. Zitnik.
Diminished free radical scavenger protein yields neurodegeneration.

20 September 2002

Mitigating the Tithonus Error: Genetic Analysis of Mortality Phenotypes. S. D. Pletcher.
Measuring maximum life-span is not sufficient.

Nuclear Fallout. M. Beckman.
Mice lacking a nucleus-bracing protein appear to age quickly.

BRCA Breakthrough. M. Leslie.
Scientists uncover job of breast cancer protein.

A Fix on AlkB. R. J. Davenport.
DNA-repair protein removes methyl groups through unprecedented mechanism.

13 September 2002

NO-Aspirin, No Atherosclerosis. R. J. Davenport.
Souped-up painkiller fights blood vessel plaques.

Outfoxing Insulin Resistance. M. Leslie.
Researchers nab the gene that adjusts response to a sugar-regulating hormone.

6 September 2002

Auto Repair on the Aging Stem Cell Superhighway. J. M. Edelberg.
Bone marrow-derived cells might offer cures for cardiovascular ills.

A Greasy Way to Die. R. J. Davenport.
Overabundance of lipids might doom motor neurons.

Totally Rad. M. Leslie.
Minor mutation hamstrings DNA-guarding protein.

30 August 2002

Subfield History: Caenorhabditis elegans as a System for Analysis of the Genetics of Aging. T. E. Johnson.
Worming our way through the past, anticipating the future.

Purging Plaque. M. Leslie.
Activating receptor in blood cells might squelch atherosclerosis.

Where's Telomerase? R. J. Davenport.
Chromosome-sealing enzyme criss-crosses the nucleus.

23 August 2002

Tunnel Vision. M. Beckman.
Common germ narrows elderly immune systems.

Giving Stroke Its Kick. R. J. Davenport.
Nitric oxide spurs tissue enzyme to damage neurons.

16 August 2002

No Supermodel. M. Leslie.
Cancer pathways might differ in mice and humans.

Nerve Verve. M. Beckman.
Nerve growth factor invigorates mice with Lou Gehrig's disease.

Menopause Mouse. M. Beckman.
Hormone-hampered rodents mimic menopause.

9 August 2002

Mitochondrial Bioenergetics, Aging, and Aging-Related Disease. D. Nicholls.
Cellular powerhouses take center stage in studies on aging.

SHIPping Out Bone Breakers. R. J. Davenport.
Protein restrains osteoclasts.

Dauer Power. M. Leslie.
Die-hard worms temporarily reverse aging.

2 August 2002

Up All Night. R. J. Davenport.
Aging disconnects body's timepieces.

Knot the Whole Story. M. Leslie.
Study snags new source of plaque ingredient.

Gauging Aging. M. Beckman.
Microscopy separates rapidly aging worms from the merely sick.

26 July 2002

Innate Immunity, Local Inflammation, and Degenerative Disease. P. L. McGeer and E. G. McGeer.
An ancient immune system gone awry can cause MAC self-attack, chronic inflammation, and tissue damage.

The Nerve of Youth. R. J. Davenport.
Roving protein might invigorate developing neurons.

19 July 2002

"Gero-Tech" Sprouts, But Will It Bloom? R. J. Davenport and J. Toy.
Researchers plant seeds, hoping to bring their academic work to market.

High-Octane Endurance--Yeast in the Metabolic Fast Lane Live Longer. E. Strauss.
Unorthodox finding prods researchers to rethink old ideas about metabolism and longevity.

12 July 2002

Perils of Procreation. M. Leslie.
Mating undermines the immune system and might shorten life.

Eyes on Epo. R. J. Davenport.
Will the anemia drug protect vision, too?

5 July 2002

Give Me Liberty or Give Me an Early Death. M. Leslie.
Wild rodents live longer than lab denizens.

Marked for Death? R. J. Davenport.
Scientists expose proteins damaged in Alzheimer's disease.

28 June 2002

Odd Couple. M. Leslie.
Two mechanisms for gene silencing unexpectedly team up.

Hematopoietic Stem Cells and Aging. J. Fuller.
The cells they are a-changin'.

21 June 2002

Oxygen? No Thanks, I'm on a Diet. V. D. Longo.
Stress resistance, oxygen consumption, and longevity are coordinately regulated in worms living under starvation conditions.

Tangled Up in Spools. R. J. Davenport.
Surprise change to chromosome protein silences genes.

14 June 2002

Murder on the Parkinson's Express. I. Chen.
A protein villain might kill brain cells by taking a neuron guardian hostage.

Ready, Set, Switch. M. Beckman.
Young neurons stop building transmitters and start building receivers.

7 June 2002

Booby Trap. C. Aschwanden.
Cancer gene spurs production of DNA-assaulting chemicals that alert and defuse rescue molecules.

VRrm Rrm. M. Beckman.
Rrm protein jump-starts idle DNA copying equipment.

31 May 2002

Head First. M. Leslie.
Defective brain response to insulin could trigger diabetes and obesity.

The Naked Mole Rat--A New Record for the Oldest Living Rodent. R. Buffenstein and J. U. M. Jarvis.
Social cooperation and underground safety pay big dividends in the life-span sweepstakes.

24 May 2002

Provoking Rage. I. Chen.
Protein fans the flames of cranky joints.

Genes, Culture, and Aging Flies--What the Lab Can and Cannot Tell Us About Natural Genetic Variation for Senescence. C. C. Spencer and D. E. L. Promislow.
Laboratory techniques might skew our view of aging.

17 May 2002

Don't Pass the Buck. S. Pyne.
Institute stakes its claim in age-related research.

Unnerved. K. Morgan.
Molecule that pumps neurons up also keeps them down.

10 May 2002

Death Comes for the Fungus. R. J. Davenport.
Yeast protein mimics mammalian cell suicide trigger.

Classic Papers Section
From Science, 1982: "Dietary Restriction in Mice Beginning at One Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence," by R. Weindruch and R. L. Walford.

3 May 2002

Meeting Report--National Institute on Aging Workshop on the Comparative Biology of Aging. H. Warner, R. A. Miller, J. Carrington.
Exploiting differences in life-span among a drove of diverse creatures.

Playful Rejuvenation. R. J. Davenport.
Researchers turn to music and other diversions for inspiration.

26 April 2002

Insulin-Like Growth Factor 1 (IGF-1) and Mammalian Aging. A. Bartke.
Genetics and physiology point toward tantalizing connections.

Picture This. R. J. Davenport.
NMR provides a glimpse of amyloid fibrils.

19 April 2002

This Is Your Brain--And This Is Your Brain on Calcium. M. Leslie.
Does calcium overload cause the fading faculties of the elderly?

Go Forth and Multiply. R. J. Davenport.
Mutations in mitochondrial DNA proliferate and take over.

12 April 2002

An Untwister's New Twist. R. J. Davenport.
Disease-causing helicase displays unanticipated talents.

Brain Saver. M. Leslie.
Compound might shield neurons during stroke.

5 April 2002

The Werner Syndrome Helicase-Nuclease. M. Fry.
One protein, many mysteries.

A Jump-Start for Replication. R. J. Davenport.
When DNA-copying machinery conks out, Bloom's syndrome helicase brings repair proteins to the rescue.

29 March 2002

Stay Mellow, Stay Young. C. Seydel.
To prolong life, ignore--don't combat--stress.

A Game of Cellular Clue. R. J. Davenport.
SOD1, with oxidative damage, in the ... mitochondria?

22 March 2002

Deciphering the Gene Expression Profile of Long-Lived Snell Mice. K. G. Becker
A balanced approach helps to determine whether gene expression changes are authentic or artifactual.

Youth Beats Experience. M. Leslie.
Older parents hatch weaker offspring.

15 March 2002

More Than a Hot Flash. R. J. Davenport
Sex hormones control a wide range of physiological processes and replacement therapy might exert similarly broad benefits.

Bulletin Board
View one researcher's list of studies on potential interventions to combat the effects of aging--and register your opinion.

8 March 2002

Of All the Nerve. M. Beckman.
Old brains grow new working cells.

Thin-Skinned. M. Leslie.
Protein props up sagging skin.

1 March 2002

Help Wanted. G. M. Martin.
Physiologists needed for "aging" research.

No Take Backs. R. J. Davenport.
Mice that can't get rid of insulin develop signs of diabetes.

22 February 2002

Is Postmenopausal Life-Span a Gift of Modern Health of a Product of Natural Selection? D. J. Holmes.
Views from endocrinology to anthropology.

Older and Stronger. C. Seydel.
Small molecule might help aged plants resist disease.

15 February 2002

Diversity Comes of Age. F. L. Bellino.
NIA supports minority investigators and research that addresses health disparities between minority and nonminority elderly populations.

Passing the BRCA1 Baton. R. J. Davenport.
Possible target of anticancer protein identified.

8 February 2002

Age Discrimination. M. Leslie.
Gene controls neuron integrity in old, not young, mice.

Inside Job. R. J. Davenport.
Alzheimer's protein kills neurons from within.

1 February 2002

Trash Talk. R. J. Davenport.
AGEs might participate in cell-death signaling.

Summertime--and the Learnin' Is Easy. J. Toy.
Students rave about courses on aging.

25 January 2002

How a clk Ticks. R. J. Davenport.
A gene slated to act at chromosome ends might play a more clear-cut role in DNA repair.

Insulin Pathway Takes a Jog. K. Miller.
Workouts might benefit young and old by employing different molecular messengers.

18 January 2002

Break Dancing. C. Seydel.
Werner syndrome protein might keep rowdy enzymes from doing a number on tattered DNA ends.

Growing Old in Style. M. Leslie.
Ponce de León spoiled a fancy suit of armor searching the swamps of Florida for the fountain of youth. Have some long-lived plants and animals succeeded where he failed?

11 January 2002

Single-Cell Analysis. M. B. Kelz et al.
Focusing with a molecular zoom lens?

Cancer and Aging. J. Campisi.
Yin, Yang, and p53.

4 January 2002

Tidbits.
Spice up your seminars with fun facts and quick quips on aging.

21 December 2001

Working Out the Kinks. R. J. Davenport.
Fly enzyme reverses protein damage, extends life-span.

Survivor! S. Hechtel.
Examples from many branches of the tree of life hint that elements of hard-core survival tactics might slow normal aging.

14 December 2001

Classifying Longevity Genes. R. A. Miller.
Six categories of genes that affect life-span.

Genes/Interventions Database.
Learn about individual longevity genes: Choose "life-span extension" on the search page in the genes/intervention database for a complete list.

7 December 2001

ATR Takes ATRIP to Fix Defects. R. J. Davenport.
Protein partners watch over the genome.

Transgenic Mice: Three Strains with Distinct Lesions in the ATM Gene. A. A. Sadighi Akha.
Rodent models of the DNA repair disorder ataxia telangiectasia.

30 November 2001

Cortical Basal Ganglionic Degeneration: A Case Study. N. Scarmeas, S. S. Chin, K. Marder.
This rare neurodegenerative disease is categorized under both parkinsonian syndromes and frontal lobe dementias.

Best of Aging on the Web.
Find genetic databases, information about neurodegenerative diseases, popular articles about aging, and much more in SAGE KE's Web links sections.

23 November 2001

Science of Aging Knowledge Map.
Find your way through the rich and complex field of aging using this novel search/browse tool.

More Than a Sum of Our Cells. K. Hopkin.
When our cells throw in the towel, are our bodies close behind?

16 November 2001

Hot Topic Orientation Article: Aging Research Grows Up. M. Leslie.
Why and how we age.

Discussion: Can Current Evolutionary Theory Explain Experimental Data on Aging?
Debate individual versus group selection.

9 November 2001

Bulletin Board: What Is the Strongest Evidence for and Against the Free Radical Theory of Aging?
Discuss this key question, and read news and overview pieces on the topic.

Genes/Interventions Database.
Feast on the eat genes, and many others that influence life-span--this web-based tool provides references, functional information, homologs, links to sequence databases, and much more on genes related to aging.

2 November 2001

Orientation Article: Detangling Alzheimer's Disease. L. Helmuth
Toward better diagnostics and possible therapeutics.

Neurodegenerative Disease Case Study: Alzheimer's Disease. L. S. Honig and S. S. Chin.
Family members often detect problems first.

26 October 2001

Classic Paper: Pleiotropy, Natural Selection, and the Evolution of Senescence. G. C. Williams.
How natural selection frequently maximizes vigor in youth at the expense of vigor at older ages.

Noteworthy This Week: Faustian Bargain. R. J. Davenport.
Cellular senescence at first prevents, later promotes cancer.

19 October 2001

News Focus: Get Some Glasses, Ump! K. Miller.
Long judged unfairly, research on aging might finally get its own NIH study sections.

Neurodegenerative Disease Case Study: Dementia with Lewy Bodies. H. Posner, S. Chin, K. Marder.
Patients mistake inanimate objects for people.

12 October 2001

Discussion: Analyzing DNA Arrays.
Talk to the experts.

Viewpoint: Realizing Wisdom. S. J. Olshansky.
A student hits the stacks and wakes up to his teacher's insight.

5 October 2001

News Synthesis: Life Extension--Our Salvation or Our Ruin? M. Barinaga.
Scientists and ethicists peek inside Pandora's box.

Perspective: Biomarkers of Aging. R. A. Miller.
A generally optimistic but not too gullible appraisal.


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