Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. cp11

CLASSIC PAPERS

DNA Repair and Longevity Assurance in Paramecium tetraurelia

Joan Smith-Sonneborn

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/cp11

Abstract: At given doses and clonal ages, ultraviolet (UV) irradiation-induced DNA damage reduced clonal life-span, but when followed by photoreactivation, extension of clonal life-span was observed. If photoreactivation preceded the UV treatment, no significant beneficial effect was detected. Because studies of others have shown that photoreactivation repair monomerizes the UV-induced cyclobutane dimers in DNA but does not affect the other photoproducts, these result indicate that DNA damage can influence the duration of clonal life-span unless that damage is repaired. Repeated treatment with UV and photoreactivation resulted in significant mean and maximal clonal life-span extension when compared with those of untreated controls, and it is assumed that the rejuvenation effect was due to the correction or prevention of some age damage.

Reproduced with permission from Science. Copyright 1979 American Association for the Advancement of Science.

Joan Smith-Sonneborn, DNA Repair and Longevity Assurance in Paramecium tetraurelia. Science 203, 1115-1117 (1979).








Science of Aging Knowledge Environment. ISSN 1539-6150