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Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. cp4

CLASSIC PAPERS

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

R. W. Hart, and R. B. Setlow

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/cp4

Abstract: The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision repair) after ultraviolet (UV) irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of ['H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, and human). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.

Reproduced by permission.

R. W. Hart, R. B. Setlow, Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species. Proc. Natl. Acad. Sci. U.S.A. 71, 2169-2173 (1974).

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