Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. cp5

CLASSIC PAPERS

Aging Can Be Genetically Dissected Into Component Processes Using Long-Lived Lines of Caenorhabditis elegans

Thomas E. Johnson

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/cp5

Abstract: The aging process has been dissected by analysis of genetic variants of the nematode Caenorhabditis elegans. Long-lived recombinant inbred lines were generated; some of these lines have mean and maximum life-spans up to 70% longer than the wild type. Longer life results from a slowing of the characteristic exponential increase in mortality rate that is typical of aging populations in all species. The length of developmental periods and the length of the reproductive period are unrelated to increased life-span. Lengthened life is due entirely to an increase in postreproductive life span. Development, reproduction, and life-span are each under independent genetic control. General motor activity decays linearly with chronological age in all genotypes. The decay in general motor activity is correlated with and is a predictor of life-span, suggesting that both share at least one common rate-determining component

Reproduced by permission.

Thomas E. Johnson, Aging Can Be Genetically Dissected Into Component Processes Using Long-Lived Lines of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 84, 3777-3781 (1987).








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