Sci. Aging Knowl. Environ., 3 October 2001
The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging
L. E. Orgelhttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/cp8
Abstract: The ways in which the accumulation of mutations might contribute to the process of aging in higher organisms or in individual clones of cells has been discussed at length. No corresponding treatment of the consequences of transcription errors in the translation of the DNA message into RNA and protein sequences seems to be available. Here I show that a consideration of the rate of accumulation of such errors leads to a paradox, the resolution of which may be relevant to the problem of aging, and that there are a number of simple experiments that should decide whether this is the case.
Reproduced by permission.
L. E. Orgel, The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging. Proc. Natl. Acad. Sci. U.S.A. 49, 517-521 (1963).
Science of Aging Knowledge Environment. ISSN 1539-6150