Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. oa4
[DOI: 10.1126/sageke.2001.1.oa4]

HOT TOPIC ORIENTATIONS

More Than a Sum of Our Cells

After decades of research, the changes in cellular function that underlie aging remain a major source of debate--and an area of intense investigation

Karen Hopkin

http://sageke.sciencemag.org/cgi/content/full/sageke;2001/1/oa4

Abstract: Cells in the body grow and die, cells in lab dishes grow and die, and individual organisms grow and die. The parallels seem maddeningly obvious, but scores of scientists still labor to draw the correct connections, to uncover the mechanisms that underlie aging in cell culture flasks and in whole animals. Do our cells stop growing, quit working, cease dividing, or start dying as we age? Do we die when our cells do, or are we somehow more than the sum of our cells? For decades, scientists have searched for evidence that links changes in cell growth, cell function, cell division, and cell death to the phenomenon we call aging. Although definitive proof eludes them, researchers continue to conduct experiments in tissue culture and in animal models, amassing information that points us toward a greater understanding of what aging is--and is not.

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Science of Aging Knowledge Environment. ISSN 1539-6150