Sci. Aging Knowl. Environ., 3 October 2001
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
David J. Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo Stocker, Ernst Hafen, Sally J. Leevers, and Linda Partridgehttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/or1
Abstract: Science 292, 104-106 (2001).
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
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