Sci. Aging Knowl. Environ., 3 October 2001
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Paola Fabrizio, Fabiola Pozza, Scott D. Pletcher, Christi M. Gendron, and Valter D. Longohttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/or3
Abstract: Science 292, 288-290 (2001).
The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.
Science of Aging Knowledge Environment. ISSN 1539-6150