Sci. Aging Knowl. Environ., 3 October 2001
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
Jada Lewis, Dennis W. Dickson, Wen-Lang Lin, Louise Chisholm, Anthony Corral, Graham Jones, Shu-Hui Yen, Naruhiko Sahara, Lisa Skipper, Debra Yager, Chris Eckman, John Hardy, Mike Hutton, and Eileen McGowanhttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/1/or4
Abstract: Science 293, 1487-1491 (2001).
JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant -amyloid precursor protein (APP), thus modulating the APP-A (-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed A deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or A influences the formation of neurofibrillary tangles. The interaction between A and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease.
Science of Aging Knowledge Environment. ISSN 1539-6150