Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. or5


Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

Blanka Rogina, Robert A. Reenan, Steven P. Nilsen, and Stephen L. Helfand;2001/1/or5

Abstract: Science 290, 2137-2140 (2000).

Aging is genetically determined and environmentally modulated. In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity. Sequence analysis revealed that the product of this gene, named Indy (for I'm not dead yet), is most closely related to a mammalian sodium dicarboxylate cotransporter--a membrane protein that transports Krebs cycle intermediates. Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly. Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span.

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Science of Aging Knowledge Environment. ISSN 1539-6150