Sci. Aging Knowl. Environ., 3 October 2001
Vol. 2001, Issue 1, p. re1
[DOI: 10.1126/sageke.2001.1.re1]


The Hunt for a Cure for Parkinson's Disease

Julie K. Andersen, Jyothi Kumar, Bharath Srinivas, Deepinder Kaur, Michael Hsu, and Subramanian Rajagopalan

The authors are in the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: jandersen{at} (J.K.A.);2001/1/re1

Key Words: Parkinson • substantia nigra • dopamine • mitochondria

Abstract: Several exciting new scientific advances have been made in the past decade toward both understanding the causes of and finding a cure for Parkinson's disease. Heartened by an acceleration in research findings in the past several years, the government has recently called for an infusion of funds from both the National Institutes of Health and private foundations into this burgeoning area of biomedical research. Most currently available conventional treatments for the disease only temporarily delay symptom presentation while doing nothing to halt disease progression. However, the rapidly accelerating pace of research in this field has left researchers hopeful that Parkinson's will be the first major age-related neurodegenerative disease for which we have a viable cure. In this article, advances in various areas of Parkinson's disease research are reviewed.

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Axonal Transport Defects in Neurodegenerative Diseases.
G. A. Morfini, M. Burns, L. I. Binder, N. M. Kanaan, N. LaPointe, D. A. Bosco, R. H. Brown Jr, H. Brown, A. Tiwari, L. Hayward, et al. (2009)
J. Neurosci. 29, 12776-12786
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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C.
G. Morfini, G. Pigino, K. Opalach, Y. Serulle, J. E. Moreira, M. Sugimori, R. R. Llinas, and S. T. Brady (2007)
PNAS 104, 2442-2447
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