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Sci. Aging Knowl. Environ., 10 October 2001
Vol. 2001, Issue 2, p. or12

OTHER RESOURCES

Parkin and Its Substrates

Christian Haass, and Philipp J. Kahle

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or12

Abstract: Science 293, 224-225 (2001).

What causes the selective degeneration of nigrostriatal dopaminergic neurons in the brains of Parkinson's disease patients? A clue comes from new work showing that two proteins implicated in Parkinson's disease, parkin and {alpha}-synuclein, normally interact in healthy neurons. The authors speculate that defective targeting of {alpha}-synuclein for degradation by parkin results in the accumulation of toxic {alpha}-synuclein aggregates that selectively kill dopaminergic neurons.

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