Sci. Aging Knowl. Environ., 10 October 2001
Parkin and Its Substrates
Christian Haass, and Philipp J. Kahlehttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or12
Abstract: Science 293, 224-225 (2001).
What causes the selective degeneration of nigrostriatal dopaminergic neurons in the brains of Parkinson's disease patients? A clue comes from new work showing that two proteins implicated in Parkinson's disease, parkin and -synuclein, normally interact in healthy neurons. The authors speculate that defective targeting of -synuclein for degradation by parkin results in the accumulation of toxic -synuclein aggregates that selectively kill dopaminergic neurons.
Science of Aging Knowledge Environment. ISSN 1539-6150