Sci. Aging Knowl. Environ., 10 October 2001
Dopamine's Reversal of Fortune
Randy D. Blakelyhttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or20
Abstract: Science 293, 2407-2409 (2001).
Dopamine transporters (DATs) are considered to be the janitors of the neurotransmission world, sucking up excess dopamine that has been released into synapses (the gaps between neurons). Not so fast, according to Blakely in his insightful Perspective. It turns out that DATs can be switched into reverse, exporting instead of importing dopamine. This switch may help in dampening down the excitability of dopaminergic neurons that have been overstimulated by the excitatory neurotransmitter glutamate.
Science of Aging Knowledge Environment. ISSN 1539-6150