Sci. Aging Knowl. Environ., 10 October 2001
A Portrait of Alzheimer Secretases
William P. Esler, and Michael S. Wolfehttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/2/or8
Abstract: Science 293, 1449-1454 (2001).
The amyloid -peptide (A) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40- to 42-amino acid peptide is formed by the cleavage of the A precursor protein (APP). The three proteases that cleave APP, -, -, and -secretases, have been implicated in the etiology of AD. -Secretase is a membrane-anchored protein with clear homology to soluble aspartyl proteases, and -secretase displays characteristics of certain membrane-tethered metalloproteases. -Secretase is apparently an oligomeric complex that includes the presenilins, which may be the catalytic component of this protease. Identification of the -, -, and -secretases provides potential targets for designing new drugs to treat AD.
Science of Aging Knowledge Environment. ISSN 1539-6150