Sci. Aging Knowl. Environ., 10 October 2001
Aging, Chromatin, and Food Restriction
Abstract: Science 289, 2062-2063 (2000).
Model organisms such as yeast have proved exceptionally valuable for revealing new information about the molecular pathways involved in the aging of cells. In her Perspective, Campisi comments on new work showing that caloric restriction increases longevity in yeast by activating the SIR2 gene, which alters the compactness of chromatin and thus regulates gene expression.
Science of Aging Knowledge Environment. ISSN 1539-6150