Sci. Aging Knowl. Environ., 24 October 2001
Vol. 2001, Issue 4, p. nf2
[DOI: 10.1126/sageke.2001.4.nf2]


Death and Aging, Together at Last

Karen Hopkin;2001/4/nf2

Abstract: Researchers may have discovered the missing link between cell death and aging, pathways that until now have seemed not to overlap. In two papers in the 19 October issue of Cell, they show that Sir2, a protein that promotes longevity in yeast and worms, counteracts the destructive tendencies of p53, a protein that determines whether cells with mutilated DNA will undergo apoptosis. The findings raise the possibility that Sir2 increases life-span by keeping cells from offing themselves and support the theory that programmed cell death might be involved in aging.

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Science of Aging Knowledge Environment. ISSN 1539-6150