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Sci. Aging Knowl. Environ., 7 November 2001
[DOI: 10.1126/sageke.2001.6.nf3]

NEWS FOCUS

Drugs Protect Mice From Pernicious Forms of Oxygen

Rabiya S. Tuma

http://sageke.sciencemag.org/cgi/content/full/sageke;2001/6/nf3

Abstract: Oxygen fuels cellular processes, but burning it creates reactive molecules that zap cellular machinery. To neutralize these cellular bullets, organisms produce an arsenal of enzymes. Animals that lack one of these enzymes--mitochondrial superoxide dismutase (SOD2)--die shortly after birth. Now new work has shown that several drugs that mimic SOD2 in the brain can prolong the lives of the mutant mice--probably by reversing some of the neurological damage that normally kills them--indicating their potential as life-extension treatments.

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Science of Aging Knowledge Environment. ISSN 1539-6150