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Sci. Aging Knowl. Environ., 14 November 2001 OTHER RESOURCESCNS Synaptogenesis Promoted by Glia-Derived CholesterolDaniela H. Mauch, Karl Nägler, Stefan Schumacher, Christian Göritz, Eva-Christina Müller, Albrecht Otto, and Frank W. Pfrieger http://sageke.sciencemag.org/cgi/content/abstract/sageke;2001/7/or23Abstract: Science 294, 1354 (2001). The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS) are poorly understood. Previous reports showed that a glia-derived factor strongly promotes synapse development in cultures of purified CNS neurons. Here, we identify this factor as cholesterol complexed to apolipoprotein E-containing lipoproteins. CNS neurons produce enough cholesterol to survive and grow, but the formation of numerous mature synapses demands additional amounts that must be provided by glia. Thus, the availability of cholesterol appears to limit synapse development. This may explain the delayed onset of CNS synaptogenesis after glia differentiation and neurobehavioral manifestations of defects in cholesterol or lipoprotein homeostasis.
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