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Sci. Aging Knowl. Environ., 9 January 2002 OTHER RESOURCESExtension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme QPamela L. Larsen, and Catherine F. Clarke http://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/1/or1Abstract: Science 295, 120 (2002). The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by ~60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.
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