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Sci. Aging Knowl. Environ., 9 January 2002
Vol. 2002, Issue 1, p. pe1
[DOI: 10.1126/sageke.2002.1.pe1]

PERSPECTIVES

Cancer and Aging: Yin, Yang, and p53

Judith Campisi

The author is at the Lawrence Berkeley National Laboratory, MS 84-171, 1 Cyclotron Road, Berkeley, CA 94720, USA. E-mail: jcampisi{at}lbl.gov

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/1/pe1

Key Words: p53 • apoptosis • senescence • premature aging • cancer • Werner

Abstract: The author discusses a recent paper published in Nature that shows that a hyperactive allele of the tumor suppressor p53 leads to the development of some premature aging phenotypes in mice. This new discovery is discussed in light of previous findings related to mechanisms of aging.

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Science of Aging Knowledge Environment. ISSN 1539-6150