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Sci. Aging Knowl. Environ., 9 January 2002 PERSPECTIVESCancer and Aging: Yin, Yang, and p53Judith Campisi The author is at the Lawrence Berkeley National Laboratory, MS 84-171, 1 Cyclotron Road, Berkeley, CA 94720, USA. E-mail: jcampisi{at}lbl.gov http://sageke.sciencemag.org/cgi/content/full/sageke;2002/1/pe1Key Words: p53 • apoptosis • senescence • premature aging • cancer • Werner
Abstract: The author discusses a recent paper published in Nature that shows that a hyperactive allele of the tumor suppressor p53 leads to the development of some premature aging phenotypes in mice. This new discovery is discussed in light of previous findings related to mechanisms of aging.
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