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Sci. Aging Knowl. Environ., 20 March 2002
Vol. 2002, Issue 11, p. nf5
[DOI: 10.1126/sageke.2002.11.nf5]

NEWS FOCUS

Stay Mellow, Stay Young

Caroline Seydel

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/11/nf5

Abstract: Mutations in single genes can extend the life-span of several model organisms, but the picture of whether and how those genes contribute to longevity in mammals remains muddy. New work links proteins involved in worm and mammalian aging and also ties in reactive oxygen species, destructive molecules that are thought to contribute to aging in a variety of creatures. Although the growing number of similar aging themes among diverse organisms is clarifying some general ideas, the details--and variations--are turning out to be a complex business.

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