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Sci. Aging Knowl. Environ., 10 April 2002 NEWS FOCUSAn Untwister's New TwistR. John Davenport http://sageke.sciencemag.org/cgi/content/full/sageke;2002/14/nf6Abstract: Defects in helicase enzymes result in a number of diseases that mimic aspects of growing old. New work shows that a helicase implicated in one of these conditions--xeroderma pigmentosum (XP)--apparently helps hormones activate genes in addition to its well-known ability to unwind DNA. The protein's newly discovered role in hormone signaling might underlie unexplained XP symptoms.
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