Sci. Aging Knowl. Environ., 16 January 2002
How a clk Ticks
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/sageke;2002/2/nf2
Abstract: New work offers tantalizing clues about possible connections between life-span, DNA damage, and the health of chromosome ends. Although the newly discovered sequence of a longevity gene suggests that it controls the length of telomeres--chromosome caps that shrink each time a cell copies its DNA--the three teams that are independently studying it disagree about that potential function. Additional clues suggest that the gene has DNA-mending capabilities, which could be the key to its life-extending powers.
Science of Aging Knowledge Environment. ISSN 1539-6150