Sci. Aging Knowl. Environ., 19 June 2002
Vol. 2002, Issue 24, p. pe10
[DOI: 10.1126/sageke.2002.24.pe10]

PERSPECTIVES

Oxygen? No Thanks, I'm on a Diet

Valter D. Longo

The author is in the Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences at the University of Southern California, Los Angeles, CA 90089-0191, USA. E-mail: vlongo{at}usc.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/24/pe10

Key Words: hypoxia • daf-2SCH9Caenorhabditis elegans • stress resistance • longevity

Abstract: In yeast and worms, mutations that extend longevity appear to simulate starvation conditions. The daf-2 pathway in worms plays a major role in life-span extension and in entry into the starvation-resistant and low-metabolism dauer phase. In a recent study published in Science Express on 13 June 2002, researchers screened for Caenorhabditis elegans mutants that survive in a low-oxygen environment and identified a number of daf-2 mutants that are resistant to hypoxia. The implications of these results are discussed in this Perspective.

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