Sci. Aging Knowl. Environ., 23 January 2002
Vol. 2002, Issue 3, p. or2


Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

Nuno Arantes-Oliveira, Javier Apfeld, Andrew Dillin, and Cynthia Kenyon;2002/3/or2

Abstract: Science 295, 502-505 (2002).

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.

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Science of Aging Knowledge Environment. ISSN 1539-6150