Sci. Aging Knowl. Environ., 23 January 2002
Vol. 2002, Issue 3, p. pe2
[DOI: 10.1126/sageke.2002.3.pe2]


Regulation of Aging by Germline Stem Cells

Marc Tatar

The author is at the Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA. E-mail: marc_tatar{at};2002/3/pe2

Key Words: Caenorhabditis elegans • germ line • stem cells • life-span • evolution

Abstract: The author discusses a recent paper published in Science (see Arantes-Oliveira) that shows that germline stem cells in the worm Caenorhabditis elegans send a signal to a steroid hormone receptor and a forkhead-family member to stimulate reproduction and shorten longevity. The author compares the new results to previous findings in the fruit fly and discusses possible mechanisms behind the inverse relationship between reproduction and life-span extension.

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Science of Aging Knowledge Environment. ISSN 1539-6150