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Sci. Aging Knowl. Environ., 7 August 2002 PERSPECTIVESMitochondrial Bioenergetics, Aging, and Aging-Related DiseaseDavid Nicholls The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: dnicholls@buckinstitute.org http://sageke.sciencemag.org/cgi/content/full/sageke;2002/31/pe12Key Words: mitochondria bioenergetics antioxidants reactive oxygen species neurodegeneration neurodegenerative disease
Abstract: In this Perspective, the author discusses some of the bioenergetic consequences of the various alterations in mitochondrial function that have been hypothesized to be associated with human aging and aging-related disease. Special focus is afforded to neurodegenerative disease. Citation: D. Nicholls, Mitochondrial Bioenergetics, Aging, and Aging-Related Disease. Science's SAGE KE (7 August 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/31/pe12
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