Sci. Aging Knowl. Environ., 28 August 2002
Vol. 2002, Issue 34, p. or11


A Cinderella Caspase Takes Center Stage

Sharad Kumar, and David L. Vaux;2002/34/or11

Abstract: Science 297, 1290-1291 (2002).

It has been thought that permeabilization of mitochondria and release of cytochrome c are early events in apoptosis that are required for the activation of caspases, the enzyme executioners of the apoptotic cascade. However, in this Perspective, Kumar and Vaux explain new findings (Lassus et al.) that implicate an often ignored caspase, caspase-2, in the early stages of apoptosis prior to mitochondrial permeabilization.

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