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Sci. Aging Knowl. Environ., 4 September 2002
Vol. 2002, Issue 35, p. pe13
[DOI: 10.1126/sageke.2002.35.pe13]

PERSPECTIVES

Auto Repair on the Aging Stem Cell Superhighway

Jay M. Edelberg

The author is in the Department of Medicine at the Weill Medical College of Cornell University, New York, NY 10021, USA. E-mail: jme2002{at}med.cornell.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/35/pe13

Key Words: cardiovascular disease • ischemic heart disease • stem cells • bone marrow • endothelial precursor cells

Abstract: Adult bone marrow stem cells offer the potential for rejuvenation of diseased or damaged tissues and organs. The greatest need for such a treatment in older individuals is to counter age-associated predisposition to cardiovascular diseases. Unfortunately, changes in senescent vascular function might limit the recruitment of bone marrow-derived precursor cells. In order to provide the patient with the conduits required to deliver bone marrow cells to damaged tissues, it is essential to develop strategies to overcome these limitations. This effort will require novel approaches to reverse aging-associated vascular dysfunction, including reharnessing the potential of stem cells from the aging bone marrow for vascular repair.

Citation: J. M. Edelberg, Auto Repair on the Aging Stem Cell Superhighway. Science's SAGE KE (4 September 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/35/pe13

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