Sci. Aging Knowl. Environ., 16 October 2002
Vol. 2002, Issue 41, p. pe16
[DOI: 10.1126/sageke.2002.41.pe16]

PERSPECTIVES

Mitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative Disease

Osamu Ogawa, Xiongwei Zhu, George Perry, and Mark A. Smith

The authors are at the Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: mas21{at}po.cwru.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/41/pe16

Key Words: coenzyme Q10 • antioxidant • mitochondria • oxidative stress • Parkinson's disease • Alzheimer disease

Abstract: An increasing body of evidence now suggests the involvement of mitochondrial abnormalities in the etiology of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer disease. In this Perspective, we describe a recent study that shows that treatment of human patients with the antioxidant coenzyme Q10, which functions in concert with certain mitochondrial enzymes, reduced the worsening of symptoms associated with PD. These findings are consistent with the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of PD and that treatments that target mitochondrial biochemistry might ameliorate the functional decline observed in patients suffering from PD.

Citation: O. Ogawa, X. Zhu, G. Perry, M. A. Smith, Mitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative Disease. Science's SAGE KE (16 October 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/41/pe16

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