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Sci. Aging Knowl. Environ., 16 October 2002 PERSPECTIVESMitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative DiseaseOsamu Ogawa, Xiongwei Zhu, George Perry, and Mark A. Smith The authors are at the Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: mas21{at}po.cwru.edu http://sageke.sciencemag.org/cgi/content/full/sageke;2002/41/pe16Key Words: coenzyme Q10 • antioxidant • mitochondria • oxidative stress • Parkinson's disease • Alzheimer disease
Abstract: An increasing body of evidence now suggests the involvement of mitochondrial abnormalities in the etiology of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer disease. In this Perspective, we describe a recent study that shows that treatment of human patients with the antioxidant coenzyme Q10, which functions in concert with certain mitochondrial enzymes, reduced the worsening of symptoms associated with PD. These findings are consistent with the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of PD and that treatments that target mitochondrial biochemistry might ameliorate the functional decline observed in patients suffering from PD. Citation: O. Ogawa, X. Zhu, G. Perry, M. A. Smith, Mitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative Disease. Science's SAGE KE (16 October 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/41/pe16
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