Sci. Aging Knowl. Environ., 20 November 2002
Having It All After All
p53 surplus staves off cancer but doesn't speed aging
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/sageke;2002/46/nf13
Abstract: Bumping up amounts of the antitumor protein p53 protects mice against cancer, but it also accelerates aging. Now scientists reveal that beefing up the p53 force in a controlled manner can thwart cancer without speeding the animals' demise. Additional work is needed to verify that the mice don't age more rapidly than normal and that p53--and not another gene--underlies the effect.
Citation: R. J. Davenport, Having It All After All. Science's SAGE KE (20 November 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/46/nf13
Science of Aging Knowledge Environment. ISSN 1539-6150