Sci. Aging Knowl. Environ., 20 November 2002
Vol. 2002, Issue 46, p. nf13
[DOI: 10.1126/sageke.2002.46.nf13]


Having It All After All

p53 surplus staves off cancer but doesn't speed aging

R. John Davenport;2002/46/nf13

Abstract: Bumping up amounts of the antitumor protein p53 protects mice against cancer, but it also accelerates aging. Now scientists reveal that beefing up the p53 force in a controlled manner can thwart cancer without speeding the animals' demise. Additional work is needed to verify that the mice don't age more rapidly than normal and that p53--and not another gene--underlies the effect.

Citation: R. J. Davenport, Having It All After All. Science's SAGE KE (20 November 2002),;2002/46/nf13

Read the Full Text

Science of Aging Knowledge Environment. ISSN 1539-6150