Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Freiburg University

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. Aging Knowl. Environ., 27 November 2002
Vol. 2002, Issue 47, p. pe18
[DOI: 10.1126/sageke.2002.47.pe18]

PERSPECTIVES

Spotlight on Nematode Mitochondria in RNAi Mega-Screen

Simon Melov

The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: smelov{at}buckinstitute.org

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/47/pe18

Key Words: C. elegans • RNAi • mitochondria • life-span

Abstract: An article in the current Advance Online Publication section of Nature Genetics reports the results of a large-scale RNA interference (RNAi) screen for genes that, when down-regulated, produce enhanced longevity in the nematode Caenorhabditis elegans. The down-regulation of a large number of genes related to energy metabolism and mitochondrial function yielded animals with increased life-spans, albeit with some additional deleterious phenotypes in some cases. In this Perspective, I discuss the implications of these results and make a plea for a more integrated approach in assessing the role of mitochondrial function, single gene mutations, and longevity.

Citation: S. Melov, Spotlight on Nematode Mitochondria in RNAi Mega-Screen. Science's SAGE KE (27 November 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/47/pe18

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products