Sci. Aging Knowl. Environ., 27 November 2002
Vol. 2002, Issue 47, p. pe18
[DOI: 10.1126/sageke.2002.47.pe18]

PERSPECTIVES

Spotlight on Nematode Mitochondria in RNAi Mega-Screen

Simon Melov

The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: smelov{at}buckinstitute.org

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/47/pe18

Key Words: C. elegans • RNAi • mitochondria • life-span

Abstract: An article in the current Advance Online Publication section of Nature Genetics reports the results of a large-scale RNA interference (RNAi) screen for genes that, when down-regulated, produce enhanced longevity in the nematode Caenorhabditis elegans. The down-regulation of a large number of genes related to energy metabolism and mitochondrial function yielded animals with increased life-spans, albeit with some additional deleterious phenotypes in some cases. In this Perspective, I discuss the implications of these results and make a plea for a more integrated approach in assessing the role of mitochondrial function, single gene mutations, and longevity.

Citation: S. Melov, Spotlight on Nematode Mitochondria in RNAi Mega-Screen. Science's SAGE KE (27 November 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/47/pe18

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