Sci. Aging Knowl. Environ., 11 December 2002
Vol. 2002, Issue 49, p. pe20
[DOI: 10.1126/sageke.2002.49.pe20]

PERSPECTIVES

Titin--Springing Back to Youth?

Fawzia Huq, E. Kevin Heist, and Roger J. Hajjar

The authors are at the Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02129, USA. E-mail: hajjar{at}cvrc.mgh.harvard.edu (R.J.H.)

http://sageke.sciencemag.org/cgi/content/full/sageke;2002/49/pe20

Key Words: titin • sarcomere • heart failure • cardiomyopathy • cardiomyocyte

Abstract: Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive elasticity on the cardiomyocyte. Several titin isoforms exist, and they display varying size and degrees of elasticity. We review two interesting reports that show how variations in titin isoforms might be implicated in cardiac failure.

Citation: F. Huq, E. K. Heist, R. J. Hajjar, Titin--Springing Back to Youth? Science's SAGE KE (11 December 2002), http://sageke.sciencemag.org/cgi/content/full/sageke;2002/49/pe20

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