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Sci. Aging Knowl. Environ., 19 March 2003
Vol. 2003, Issue 11, p. or3

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A Matter of Life or Death

Rama Ranganathan

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2003/11/or3

Abstract: Science 299, 1677-1679 (2003).

Death of retinal photoreceptor cells underlies many blinding diseases, such as retinitis pigmentosa and age-related macular degeneration. In a Perspective, Ranganathan explores new work that starts to unravel the relation between visual signaling pathways and the processes of apoptosis and necrosis. An intriguing new finding is that accumulation of the sphingolipid ceramide stimulates both necrosis and apoptosis of fly photoreceptor cells (see Science paper by Acharya et al.).

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Science of Aging Knowledge Environment. ISSN 1539-6150