Sci. Aging Knowl. Environ., 2 April 2003
Vol. 2003, Issue 13, p. dn1
[DOI: 10.1126/sageke.2003.13.dn1]


Frontotemporal Dementia

Lawrence S. Honig, Karen Bell, and Steven S. Chin

The authors are at Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, and the Departments of Neurology and Pathology, New York, NY 10032, USA. E-mail: lh456{at} (L.S.H.);2003/13/dn1

Key Words: frontotemporal dementia • frontal lobe • temporal lobe • tau

Abstract: In this case study, we describe the symptoms, neuropsychological testing, and brain pathology of a man with frontotemporal dementia (FTD). FTD most often presents with either a change in personality or behavior, such as social withdrawal, increased gregariousness, disinhibition, or obsessive behaviors; or with impairment of language function. Memory difficulties are common, but usually are less prominent than these other symptoms in the early stages of the disease. Frequently, psychiatric diagnoses are initially the primary consideration. Cases may be either familial or sporadic. In this familial case, an autopsy was ultimately performed and revealed findings characteristic of FTD, with grossly evident focal brain degeneration in the frontal and temporal regions, microscopic signs of gliosis, and cellular abnormalities of the intracellular microtubule-associated protein tau.

Citation: L. S. Honig, K. Bell, S. S. Chin, Frontotemporal Dementia. Sci. SAGE KE 2003, dn1 (2 April 2003);2003/13/dn1

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