Sci. Aging Knowl. Environ., 23 April 2003
Vol. 2003, Issue 16, p. pe8
[DOI: 10.1126/sageke.2003.16.pe8]


Is DNA Cut Out for a Long Life?

David Sinclair

The author is in the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: David_Sinclair{at};2003/16/pe8

Key Words: DNA repair • yeast • DNA damage • chronological aging

Abstract: Much attention has been focused on the DNA repair hypothesis of aging. Studies in mammals that seek to test the validity of this model are complicated by both the functional redundancy and the essential nature of genes involved in the repair process. Compared to mammals, the study of DNA repair and aging in yeast has considerably fewer complicating factors. In this Perspective, I discuss results presented in this month's issue of Aging Cell that address whether the types of DNA damage repaired by the base excision repair pathway cause aging in yeast.

Citation: D. Sinclair, Is DNA Cut Out for a Long Life? Sci. SAGE KE 2003, pe8 (23 April 2003);2003/16/pe8

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