Sci. Aging Knowl. Environ., 30 April 2003
Vol. 2003, Issue 17, p. pe9
[DOI: 10.1126/sageke.2003.17.pe9]


Direct and Indirect Transcriptional Targets of DAF-16

Pamela L. Larsen

The author is in the Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. E-mail: larsenp{at};2003/17/pe9

Abstract: Several genes involved in the determination of life span have been identified by mutation in the free-living soil nematode Caenorhabditis elegans. One of the key pathways studied in the context of life span is the DAF-2 pathway. The daf-2 gene is homologous to the insulin and insulin-like growth factor 1 receptor families. A downstream gene, daf-16, encodes a protein that is homologous to the forkhead transcription factor. A study by McElwee, Bubb, and Thomas, published in the current issue of Aging Cell, used genome-scale gene expression analysis to search for genes that are differentially expressed between long-lived daf-2(e1370) and short-lived daf-16(m27);daf-2(e1370) animals. In doing so, they identified candidate direct and indirect targets of DAF-16. In this Perspective, I discuss the results of this study.

Citation: P. L. Larsen, Direct and Indirect Transcriptional Targets of DAF-16. Sci. SAGE KE 2003, pe9 (30 April 2003);2003/17/pe9

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