Sci. Aging Knowl. Environ., 14 May 2003
Vol. 2003, Issue 19, p. nf10
[DOI: 10.1126/sageke.2003.19.nf10]

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Hungering for Simplicity

Calorie restriction activates stress-based longevity pathway

Evelyn Strauss

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/19/nf10

Abstract: New work on yeast indicates that glucose restriction goads a protein without previously known antiaging talents to activate a longevity pathway. The protein, Pnc1p, acts through an enzyme called Sir2p that slows aging in several organisms, and the new results suggest an unexpected means of controlling Sir2p: with the small molecule nicotinamide. The work also supports the notions that glucose restriction activates a stress-response longevity pathway and that hormesis can counteract aging.

Citation: E. Strauss, Hungering for Simplicity. Sci. SAGE KE 2003, nf10 (14 May 2003)
http://sageke.sciencemag.org/cgi/content/full/sageke;2003/19/nf10

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