Sci. Aging Knowl. Environ., 14 May 2003
Hungering for Simplicity
Calorie restriction activates stress-based longevity pathway
Abstract: New work on yeast indicates that glucose restriction goads a protein without previously known antiaging talents to activate a longevity pathway. The protein, Pnc1p, acts through an enzyme called Sir2p that slows aging in several organisms, and the new results suggest an unexpected means of controlling Sir2p: with the small molecule nicotinamide. The work also supports the notions that glucose restriction activates a stress-response longevity pathway and that hormesis can counteract aging.
Citation: E. Strauss, Hungering for Simplicity. Sci. SAGE KE 2003, nf10 (14 May 2003)
Science of Aging Knowledge Environment. ISSN 1539-6150