Sci. Aging Knowl. Environ., 4 June 2003
Vol. 2003, Issue 22, p. pe13
[DOI: 10.1126/sageke.2003.22.pe13]

PERSPECTIVES

Creating New Neurons in Old Brains

Phyllis M. Wise

The author is in the Department of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, University of California, Davis, Davis, CA 95616, USA. E-mail: pmwise{at}ucdavis.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/22/pe13

Key Words: Neurogenesis • growth factor • fibroblast growth factor • heparin-binding epidermal growth factor-like growth factor • injury

Abstract: The brains of aged rodents exhibit decreased neurogenesis as compared to those of young adult rodents. Basal neurogenesis has previously been shown to increase in the young adult rodent brain upon the administration of growth factors. However, it is unknown whether similar treatment can affect this process in the aging brain. A recent paper published in the June 2003 issue of the journal Aging Cell reveals that two growth factors can stimulate neurogensis in aged mice. This result raises the possibility that similar treatments may be used in humans to help maintain normal brain function in old age.

Citation: P. M. Wise, Creating New Neurons in Old Brains. Sci. SAGE KE 2003, pe13 (4 June 2003)
http://sageke.sciencemag.org/cgi/content/full/sageke;2003/22/pe13

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Science of Aging Knowledge Environment. ISSN 1539-6150