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Sci. Aging Knowl. Environ., 11 June 2003 HOT TOPIC ORIENTATIONSImmunity ChallengeDeciphering how the immune system changes with age might reveal ways to bolster resistance to infection and cool inflammation in the elderlyR. John Davenport http://sageke.sciencemag.org/cgi/content/full/sageke;2003/23/oa1Abstract: As people get older, their immune systems falter. The elderly are more susceptible to infections than youngsters are, and hyperactive inflammatory responses appear to contribute to some age-associated illnesses, including Alzheimer's disease and atherosclerosis. Investigating the effect of aging on the immune system was once a scientific stepchild, but card-carrying immunologists are now tackling the problem head-on. Despite the immune system's complexity, researchers have started to make sense of how its components change with age. As the research progresses, scientists hope to bolster elderly people's response to infectious diseases and quiet the inflammation that can make aging a painful experience.
Citation: R. J. Davenport, Immunity Challenge. Sci. SAGE KE 2003, oa1 (11 June 2003)
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