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Sci. Aging Knowl. Environ., 18 June 2003 PERSPECTIVESUrine-Concentrating Ability in the Aging KidneyJeff M. Sands The author is in the Renal Division, in the Department of Medicine and Department of Physiology, at Emory University School of Medicine, Atlanta, GA 30322, USA. E-mail: jsands{at}emory.edu http://sageke.sciencemag.org/cgi/content/full/sageke;2003/24/pe15Key Words: aquaporin • water • urea • vasopressin • antidiuretic hormone • kidney
Abstract: Urine-concentrating ability is decreased in the aging mammalian kidney. Studies have revealed various changes in kidney function that occur with aging and may explain the reduced ability to concentrate urine. Recently, the genes encoding many of the water- and solute-transport proteins and the vasopressin receptor, all of which are involved in urine concentration, have been cloned. Therefore, the molecular mechanisms that cause the reduction in urine-concentrating ability with aging can now be deciphered. In this Perspective, I discuss recent experiments designed to characterize this change in kidney function in aging mammals.
Citation: J. M. Sands, Urine-Concentrating Ability in the Aging Kidney. Sci. SAGE KE 2003, pe15 (18 June 2003)
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