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Sci. Aging Knowl. Environ., 25 June 2003
Vol. 2003, Issue 25, p. pe16
[DOI: 10.1126/sageke.2003.25.pe16]

PERSPECTIVES

Does Anti-Aging Equal Anti-Microbial?

Gordon J. Lithgow

The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: glithgow{at}buckinstitute.org

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/25/pe16

Key Words: anti-microbial • insulin • insulin-like growth factor 1 • bacteria • Caenorhabditis elegans

Abstract: Aging is the dominant risk factor for human disease in developed countries. Could it be that a wide variety of disease states all have their origins in a common mechanism? Major signaling pathways that determine the rate of aging, such as the insulin/insulin-like growth factor 1 (IGF-1) pathway, might give clues to the nature of this major disease risk factor. It has now been shown that insulin/IGF-1 signaling influences Caenorhabditis elegans resistance to bacteria in such a way that long-lived worms are stress-resistant and slow to succumb to infection. Perhaps enhanced innate immunity is a feature of genetically determined longevity.

Citation: G. J. Lithgow, Does Anti-Aging Equal Anti-Microbial? Sci. SAGE KE 2003, pe16 (25 June 2003)
http://sageke.sciencemag.org/cgi/content/full/sageke;2003/25/pe16

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