Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 25 June 2003
Vol. 2003, Issue 25, p. pe16
[DOI: 10.1126/sageke.2003.25.pe16]

PERSPECTIVES

Does Anti-Aging Equal Anti-Microbial?

Gordon J. Lithgow

The author is at the Buck Institute for Age Research, Novato, CA 94945, USA. E-mail: glithgow{at}buckinstitute.org

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/25/pe16

Key Words: anti-microbial • insulin • insulin-like growth factor 1 • bacteria • Caenorhabditis elegans

Abstract: Aging is the dominant risk factor for human disease in developed countries. Could it be that a wide variety of disease states all have their origins in a common mechanism? Major signaling pathways that determine the rate of aging, such as the insulin/insulin-like growth factor 1 (IGF-1) pathway, might give clues to the nature of this major disease risk factor. It has now been shown that insulin/IGF-1 signaling influences Caenorhabditis elegans resistance to bacteria in such a way that long-lived worms are stress-resistant and slow to succumb to infection. Perhaps enhanced innate immunity is a feature of genetically determined longevity.

Citation: G. J. Lithgow, Does Anti-Aging Equal Anti-Microbial? Sci. SAGE KE 2003, pe16 (25 June 2003)
http://sageke.sciencemag.org/cgi/content/full/sageke;2003/25/pe16

Read the Full Text







To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150