Sci. Aging Knowl. Environ., 2 July 2003
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor
Ao-Lin Hsu, Coleen T. Murphy, and Cynthia Kenyonhttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2003/26/or10
Abstract: Science 300, 1142-1145 (2003).
The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends life-span. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.
Science of Aging Knowledge Environment. ISSN 1539-6150