Sci. Aging Knowl. Environ., 6 August 2003
Vol. 2003, Issue 31, p. pe22
[DOI: 10.1126/sageke.2003.31.pe22]


Diverse Dealings of the Werner Helicase/Nuclease

Wen-Hsing Cheng, and Vilhelm A. Bohr

The authors are in the Laboratory of Molecular Gerontology at the National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. E-mail: BohrV{at};2003/31/pe22

Key Words: DNA repair • recombination • Werner • progeroid

Abstract: The human Werner syndrome is a model for the process of aging. The protein that is mutated in Werner syndrome, WRN, exhibits three catalytic activities: a 3'-to-5' helicase, a 3'-to-5' exonuclease, and an adenosine triphosphatase activity. WRN interacts with a variety of proteins and has been implicated in many aspects of DNA metabolism. A recent paper by Chen et al. published in the August 2003 issue of Aging Cell sheds some light on the multifunctional nature of WRN. It suggests that WRN may be considered as a structural protein, providing a plausible conceptual basis for the many WRN protein-protein interactions.

Citation: W.-H. Cheng, V. A. Bohr, Diverse Dealings of the Werner Helicase/Nuclease. Sci. SAGE KE 2003, pe22 (6 August 2003);2003/31/pe22

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Werner Syndrome Protein--Unwinding Function to Explain Disease.
R. J. Monnat Jr. and Y. Saintigny (2004)
Sci. Aging Knowl. Environ. 2004, re3
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