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Sci. Aging Knowl. Environ., 20 August 2003
Vol. 2003, Issue 33, p. pe24
[DOI: 10.1126/sageke.2003.33.pe24]

PERSPECTIVES

The Persistence of Senescence

Norman E. Sharpless

The author is in the Departments of Medicine and Genetics, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. E-mail: norman_sharpless{at}med.unc.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/33/pe24

Key Words: p16INK4a • p53 • Rb • senescence • p21 • Ink4a/Arf

Abstract: Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications (1, 2) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well.

Citation: N. E. Sharpless, The Persistence of Senescence. Sci. SAGE KE 2003 (33), pe24 (2003).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Search for Biomarkers of Aging: Next Stop INK4a/ARF Locus.
G. P. Dimri (2004)
Sci. Aging Knowl. Environ. 2004, pe40
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