Sci. Aging Knowl. Environ., 1 October 2003
Vol. 2003, Issue 39, p. or18

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An Age of Instability

David A. Sinclair

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2003/39/or18

Abstract: Science 301, 1859-1860 (2003).

It is well established that as we age our cancer risk increases dramatically. As Sinclair explains in his Perspective, the link between cancer and aging is now solidified by new work in budding yeast (McMurray and Gottschling). As yeast cells age there is a marked increase in their genetic instability (a hallmark of cancer), which is independent of the mechanism that determines their life span.

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Science of Aging Knowledge Environment. ISSN 1539-6150