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Sci. Aging Knowl. Environ., 1 October 2003
Vol. 2003, Issue 39, p. pe27
[DOI: 10.1126/sageke.2003.39.pe27]

PERSPECTIVES

Ceramide, Stress, and a "LAG" in Aging

Lina M. Obeid, and Yusuf A. Hannun

Lina M. Obeid is in the Ralph H. Johnson Veterans Affairs Medical Center, Department of Veteran Affairs, Charleston, SC 29401, USA; the Department of Medicine, Division of General Internal Medicine, University of South Carolina, Charleston, SC 29425, USA; and the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. Yusuf A. Hannun is in the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. E-mail: obeidl{at}musc.edu

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/39/pe27

Key Words: ceramide • LAG1 • stress • calorie restriction • insulin • IGF-1

Abstract: Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.

Citation: L. M. Obeid, Y. A. Hannun, Ceramide, Stress, and a "LAG" in Aging. Sci. SAGE KE 2003 (39), pe27 (2003).

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Science of Aging Knowledge Environment. ISSN 1539-6150