Sci. Aging Knowl. Environ., 5 November 2003
Vol. 2003, Issue 44, p. nw150
[DOI: 10.1126/sageke.2003.44.nw150]

NOTEWORTHY ARTICLES

Crypt-ic Message

Stem cells in the gut pile up mutations in mitochondrial DNA

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/44/nw150

Key Words: cytochrome c oxidase • succinate dehydrogenase • heteroplasmy • homoplasmy

Abstract: Dark crypts swarming with cloned mutants: It's not the premise for a grade B horror film but the result of a new study. The work is the first to reveal that intestinal stem cells amass DNA mutations in their mitochondria, and it raises the possibility that the accumulation of such defects as we age could choke stem cells.

Citation: R. J. Davenport, Crypt-ic Message. Sci. Aging Knowl. Environ. 2003 (44), nw150 (2003).

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