Sci. Aging Knowl. Environ., 12 November 2003
Vol. 2003, Issue 45, p. or24

OTHER RESOURCES

Yeast Life Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Rozalyn M. Anderson, Magda Latorre-Esteves, Ana Rute Neves, Siva Lavu, Oliver Medvedik, Christopher Taylor, Konrad T. Howitz, Helena Santos, and David A. Sinclair

http://sageke.sciencemag.org/cgi/content/abstract/sageke;2003/45/or24

Abstract: Science 6 November 2003 (10.1126/science.1088697) (Science Express Reports)

Calorie restriction (CR) slows aging in numerous species. In the yeast S. cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homolog SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

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